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Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial

IMPORTANCE: Common mental disorders (CMD), which include depression and anxiety, are prevalent among people living with HIV and are associated with suboptimal antiretroviral therapy (ART) adherence. OBJECTIVE: To assess the effect of a lay health worker–led psychological intervention on ART adherenc...

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Autores principales: Haas, Andreas D., Kunzekwenyika, Cordelia, Manzero, Josphat, Hossmann, Stefanie, Limacher, Andreas, van Dijk, Janneke H., Manhibi, Ronald, von Groote, Per, Hobbins, Michael A., Verhey, Ruth, Egger, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346120/
https://www.ncbi.nlm.nih.gov/pubmed/37440230
http://dx.doi.org/10.1001/jamanetworkopen.2023.23205
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author Haas, Andreas D.
Kunzekwenyika, Cordelia
Manzero, Josphat
Hossmann, Stefanie
Limacher, Andreas
van Dijk, Janneke H.
Manhibi, Ronald
von Groote, Per
Hobbins, Michael A.
Verhey, Ruth
Egger, Matthias
author_facet Haas, Andreas D.
Kunzekwenyika, Cordelia
Manzero, Josphat
Hossmann, Stefanie
Limacher, Andreas
van Dijk, Janneke H.
Manhibi, Ronald
von Groote, Per
Hobbins, Michael A.
Verhey, Ruth
Egger, Matthias
author_sort Haas, Andreas D.
collection PubMed
description IMPORTANCE: Common mental disorders (CMD), which include depression and anxiety, are prevalent among people living with HIV and are associated with suboptimal antiretroviral therapy (ART) adherence. OBJECTIVE: To assess the effect of a lay health worker–led psychological intervention on ART adherence, virologic suppression, and mental health symptoms. DESIGN, SETTING, AND PARTICIPANTS: Open-label pragmatic cluster trial with 1:1 block randomization of 16 health facilities in rural Bikita, Zimbabwe. Recruitment occurred from October 2018 to December 2019, and participants were followed up for 12 months, ending in December 2020. Participants were adults aged 18 years and older, who spoke English or Shona, screened positive for CMD (Shona Symptoms Questionnaire [SSQ]-14 score ≥9), received first-line ART for 6 or more months, had no World Health Organization stage 4 disease, no psychosis, were not pregnant, and provided informed consent. Data were analyzed from March 2021 to February 2022. INTERVENTION: The Friendship Bench, consisting of 6 lay health worker–led weekly problem-solving therapy sessions and optional peer-led group support. MAIN OUTCOMES AND MEASURES: The primary outcome was mean adherence during 2 to 6 months of follow-up, and the secondary outcomes were mean adherence during 1 to 12 months of follow-up, change in SSQ-14 and Patient Health Questionnaire (PHQ-9) scores (3, 6, 9, and 12 months), and viral load suppression (6 and 12 months). RESULTS: A total of 516 participants were recruited (244 in Friendship Bench and 272 in enhanced standard care facilities); 438 (84.9%) were female and the mean (SD) age was 45.6 (10.9) years. Mean (SD) adherence between 2 to 6 months was 89.9% (18.4%) in the Friendship Bench group and 87.2% (20.1%) in the control group. The intervention had no statistically significant effect on adherence between 2 to 6 months (unadjusted mean difference, 1.93 percentage points; 95% CI, −1.20 to 5.06 percentage points; P = .23), between months 1 to 12 (mean difference 0.79 percentage points; 95% CI, −2.14 to 3.71 percentage points; P = .60), or viral suppression. Declines in SSQ-14 scores from baseline to 3 months (difference, −1.65; 95% CI, −3.07 to −0.24), 6 months (difference, −1.57; 95% CI, −2.98 to −0.15), and 9 months (difference, −1.63; 95% CI, −3.05 to −0.22) were greater in the Friendship Bench than the standard care group (P < .05). There were no differences in the decline in the SSQ-14 scores from baseline to 12 months and in declines in PHQ-9 scores from baseline to 3, 6, 9, and 12 months. CONCLUSIONS AND RELEVANCE: In this randomized trial of HIV-positive participants with CMD, the Friendship Bench intervention had no effect on adherence and viral suppression, possibly due to the absence of skill-based adherence training and a ceiling effect. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03704805
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spelling pubmed-103461202023-07-15 Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial Haas, Andreas D. Kunzekwenyika, Cordelia Manzero, Josphat Hossmann, Stefanie Limacher, Andreas van Dijk, Janneke H. Manhibi, Ronald von Groote, Per Hobbins, Michael A. Verhey, Ruth Egger, Matthias JAMA Netw Open Original Investigation IMPORTANCE: Common mental disorders (CMD), which include depression and anxiety, are prevalent among people living with HIV and are associated with suboptimal antiretroviral therapy (ART) adherence. OBJECTIVE: To assess the effect of a lay health worker–led psychological intervention on ART adherence, virologic suppression, and mental health symptoms. DESIGN, SETTING, AND PARTICIPANTS: Open-label pragmatic cluster trial with 1:1 block randomization of 16 health facilities in rural Bikita, Zimbabwe. Recruitment occurred from October 2018 to December 2019, and participants were followed up for 12 months, ending in December 2020. Participants were adults aged 18 years and older, who spoke English or Shona, screened positive for CMD (Shona Symptoms Questionnaire [SSQ]-14 score ≥9), received first-line ART for 6 or more months, had no World Health Organization stage 4 disease, no psychosis, were not pregnant, and provided informed consent. Data were analyzed from March 2021 to February 2022. INTERVENTION: The Friendship Bench, consisting of 6 lay health worker–led weekly problem-solving therapy sessions and optional peer-led group support. MAIN OUTCOMES AND MEASURES: The primary outcome was mean adherence during 2 to 6 months of follow-up, and the secondary outcomes were mean adherence during 1 to 12 months of follow-up, change in SSQ-14 and Patient Health Questionnaire (PHQ-9) scores (3, 6, 9, and 12 months), and viral load suppression (6 and 12 months). RESULTS: A total of 516 participants were recruited (244 in Friendship Bench and 272 in enhanced standard care facilities); 438 (84.9%) were female and the mean (SD) age was 45.6 (10.9) years. Mean (SD) adherence between 2 to 6 months was 89.9% (18.4%) in the Friendship Bench group and 87.2% (20.1%) in the control group. The intervention had no statistically significant effect on adherence between 2 to 6 months (unadjusted mean difference, 1.93 percentage points; 95% CI, −1.20 to 5.06 percentage points; P = .23), between months 1 to 12 (mean difference 0.79 percentage points; 95% CI, −2.14 to 3.71 percentage points; P = .60), or viral suppression. Declines in SSQ-14 scores from baseline to 3 months (difference, −1.65; 95% CI, −3.07 to −0.24), 6 months (difference, −1.57; 95% CI, −2.98 to −0.15), and 9 months (difference, −1.63; 95% CI, −3.05 to −0.22) were greater in the Friendship Bench than the standard care group (P < .05). There were no differences in the decline in the SSQ-14 scores from baseline to 12 months and in declines in PHQ-9 scores from baseline to 3, 6, 9, and 12 months. CONCLUSIONS AND RELEVANCE: In this randomized trial of HIV-positive participants with CMD, the Friendship Bench intervention had no effect on adherence and viral suppression, possibly due to the absence of skill-based adherence training and a ceiling effect. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03704805 American Medical Association 2023-07-13 /pmc/articles/PMC10346120/ /pubmed/37440230 http://dx.doi.org/10.1001/jamanetworkopen.2023.23205 Text en Copyright 2023 Haas AD et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Haas, Andreas D.
Kunzekwenyika, Cordelia
Manzero, Josphat
Hossmann, Stefanie
Limacher, Andreas
van Dijk, Janneke H.
Manhibi, Ronald
von Groote, Per
Hobbins, Michael A.
Verhey, Ruth
Egger, Matthias
Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial
title Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial
title_full Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial
title_fullStr Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial
title_full_unstemmed Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial
title_short Effect of the Friendship Bench Intervention on Antiretroviral Therapy Outcomes and Mental Health Symptoms in Rural Zimbabwe: A Cluster Randomized Trial
title_sort effect of the friendship bench intervention on antiretroviral therapy outcomes and mental health symptoms in rural zimbabwe: a cluster randomized trial
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346120/
https://www.ncbi.nlm.nih.gov/pubmed/37440230
http://dx.doi.org/10.1001/jamanetworkopen.2023.23205
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