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Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8–13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morph...

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Autores principales: Lejman-Larysz, Katarzyna, Golara, Anna, Baranowska, Marta, Kozłowski, Mateusz, Guzik, Paweł, Szydłowska, Iwona, Nawrocka-Rutkowska, Jolanta, Sowińska-Przepiera, Elżbieta, Cymbaluk-Płoska, Aneta, Brodowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346142/
https://www.ncbi.nlm.nih.gov/pubmed/37447279
http://dx.doi.org/10.3390/nu15132952
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author Lejman-Larysz, Katarzyna
Golara, Anna
Baranowska, Marta
Kozłowski, Mateusz
Guzik, Paweł
Szydłowska, Iwona
Nawrocka-Rutkowska, Jolanta
Sowińska-Przepiera, Elżbieta
Cymbaluk-Płoska, Aneta
Brodowska, Agnieszka
author_facet Lejman-Larysz, Katarzyna
Golara, Anna
Baranowska, Marta
Kozłowski, Mateusz
Guzik, Paweł
Szydłowska, Iwona
Nawrocka-Rutkowska, Jolanta
Sowińska-Przepiera, Elżbieta
Cymbaluk-Płoska, Aneta
Brodowska, Agnieszka
author_sort Lejman-Larysz, Katarzyna
collection PubMed
description Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8–13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecological examination, anthropometric measurements were taken, including height, weight, waist, and hip circumference, and blood pressure was measured using the Korotkow method. In the female patients, the following parameters were also determined from the blood: follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, TSH, ft4, prolactin (PRL), total testosterone, DHEASO4, 17-hydroxyprogesterone (17-OHP), sex-hormone-binding globulin (SHBG), androstendione, 25(OH) vitamin D3 metabolite. The majority of the patients with polycystic ovary syndrome were found to have deficient or suboptimal serum vitamin D levels, and the effects of vitamin D on the SHBG levels and free-androgen indices in these patients was examined. The effects of vitamin D on the incidence of metabolic syndrome and BMI, waist-to-hip ratio, waist circumference, and blood pressure in patients with polycystic ovary syndrome were also found.
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spelling pubmed-103461422023-07-15 Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome Lejman-Larysz, Katarzyna Golara, Anna Baranowska, Marta Kozłowski, Mateusz Guzik, Paweł Szydłowska, Iwona Nawrocka-Rutkowska, Jolanta Sowińska-Przepiera, Elżbieta Cymbaluk-Płoska, Aneta Brodowska, Agnieszka Nutrients Article Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8–13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecological examination, anthropometric measurements were taken, including height, weight, waist, and hip circumference, and blood pressure was measured using the Korotkow method. In the female patients, the following parameters were also determined from the blood: follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, TSH, ft4, prolactin (PRL), total testosterone, DHEASO4, 17-hydroxyprogesterone (17-OHP), sex-hormone-binding globulin (SHBG), androstendione, 25(OH) vitamin D3 metabolite. The majority of the patients with polycystic ovary syndrome were found to have deficient or suboptimal serum vitamin D levels, and the effects of vitamin D on the SHBG levels and free-androgen indices in these patients was examined. The effects of vitamin D on the incidence of metabolic syndrome and BMI, waist-to-hip ratio, waist circumference, and blood pressure in patients with polycystic ovary syndrome were also found. MDPI 2023-06-29 /pmc/articles/PMC10346142/ /pubmed/37447279 http://dx.doi.org/10.3390/nu15132952 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lejman-Larysz, Katarzyna
Golara, Anna
Baranowska, Marta
Kozłowski, Mateusz
Guzik, Paweł
Szydłowska, Iwona
Nawrocka-Rutkowska, Jolanta
Sowińska-Przepiera, Elżbieta
Cymbaluk-Płoska, Aneta
Brodowska, Agnieszka
Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
title Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
title_full Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
title_fullStr Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
title_full_unstemmed Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
title_short Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
title_sort influence of vitamin d on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346142/
https://www.ncbi.nlm.nih.gov/pubmed/37447279
http://dx.doi.org/10.3390/nu15132952
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