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Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8–13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morph...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346142/ https://www.ncbi.nlm.nih.gov/pubmed/37447279 http://dx.doi.org/10.3390/nu15132952 |
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author | Lejman-Larysz, Katarzyna Golara, Anna Baranowska, Marta Kozłowski, Mateusz Guzik, Paweł Szydłowska, Iwona Nawrocka-Rutkowska, Jolanta Sowińska-Przepiera, Elżbieta Cymbaluk-Płoska, Aneta Brodowska, Agnieszka |
author_facet | Lejman-Larysz, Katarzyna Golara, Anna Baranowska, Marta Kozłowski, Mateusz Guzik, Paweł Szydłowska, Iwona Nawrocka-Rutkowska, Jolanta Sowińska-Przepiera, Elżbieta Cymbaluk-Płoska, Aneta Brodowska, Agnieszka |
author_sort | Lejman-Larysz, Katarzyna |
collection | PubMed |
description | Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8–13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecological examination, anthropometric measurements were taken, including height, weight, waist, and hip circumference, and blood pressure was measured using the Korotkow method. In the female patients, the following parameters were also determined from the blood: follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, TSH, ft4, prolactin (PRL), total testosterone, DHEASO4, 17-hydroxyprogesterone (17-OHP), sex-hormone-binding globulin (SHBG), androstendione, 25(OH) vitamin D3 metabolite. The majority of the patients with polycystic ovary syndrome were found to have deficient or suboptimal serum vitamin D levels, and the effects of vitamin D on the SHBG levels and free-androgen indices in these patients was examined. The effects of vitamin D on the incidence of metabolic syndrome and BMI, waist-to-hip ratio, waist circumference, and blood pressure in patients with polycystic ovary syndrome were also found. |
format | Online Article Text |
id | pubmed-10346142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103461422023-07-15 Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome Lejman-Larysz, Katarzyna Golara, Anna Baranowska, Marta Kozłowski, Mateusz Guzik, Paweł Szydłowska, Iwona Nawrocka-Rutkowska, Jolanta Sowińska-Przepiera, Elżbieta Cymbaluk-Płoska, Aneta Brodowska, Agnieszka Nutrients Article Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8–13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecological examination, anthropometric measurements were taken, including height, weight, waist, and hip circumference, and blood pressure was measured using the Korotkow method. In the female patients, the following parameters were also determined from the blood: follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, TSH, ft4, prolactin (PRL), total testosterone, DHEASO4, 17-hydroxyprogesterone (17-OHP), sex-hormone-binding globulin (SHBG), androstendione, 25(OH) vitamin D3 metabolite. The majority of the patients with polycystic ovary syndrome were found to have deficient or suboptimal serum vitamin D levels, and the effects of vitamin D on the SHBG levels and free-androgen indices in these patients was examined. The effects of vitamin D on the incidence of metabolic syndrome and BMI, waist-to-hip ratio, waist circumference, and blood pressure in patients with polycystic ovary syndrome were also found. MDPI 2023-06-29 /pmc/articles/PMC10346142/ /pubmed/37447279 http://dx.doi.org/10.3390/nu15132952 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lejman-Larysz, Katarzyna Golara, Anna Baranowska, Marta Kozłowski, Mateusz Guzik, Paweł Szydłowska, Iwona Nawrocka-Rutkowska, Jolanta Sowińska-Przepiera, Elżbieta Cymbaluk-Płoska, Aneta Brodowska, Agnieszka Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome |
title | Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome |
title_full | Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome |
title_fullStr | Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome |
title_full_unstemmed | Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome |
title_short | Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome |
title_sort | influence of vitamin d on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346142/ https://www.ncbi.nlm.nih.gov/pubmed/37447279 http://dx.doi.org/10.3390/nu15132952 |
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