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A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle
Zynamite PX(®), a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite(®) + 140 mg quercetin/8 h for 2 days). Then, they...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346248/ https://www.ncbi.nlm.nih.gov/pubmed/37447175 http://dx.doi.org/10.3390/nu15132848 |
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author | Martinez-Canton, Miriam Galvan-Alvarez, Victor Garcia-Gonzalez, Eduardo Gallego-Selles, Angel Gelabert-Rebato, Miriam Garcia-Perez, Giovanni Santana, Alfredo Lopez-Rios, Laura Vega-Morales, Tanausu Martin-Rincon, Marcos Calbet, Jose A. L. |
author_facet | Martinez-Canton, Miriam Galvan-Alvarez, Victor Garcia-Gonzalez, Eduardo Gallego-Selles, Angel Gelabert-Rebato, Miriam Garcia-Perez, Giovanni Santana, Alfredo Lopez-Rios, Laura Vega-Morales, Tanausu Martin-Rincon, Marcos Calbet, Jose A. L. |
author_sort | Martinez-Canton, Miriam |
collection | PubMed |
description | Zynamite PX(®), a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite(®) + 140 mg quercetin/8 h for 2 days). Then, they performed incremental exercise to exhaustion (IE) followed by occlusion of the circulation in one leg for 60 s. Afterwards, the cuff was released, and a 30 s sprint was performed, followed by 90 s circulatory occlusion (same leg). Vastus lateralis muscle biopsies were obtained at baseline, 20 s after IE (occluded leg) and 10 s after Wingate (occluded leg), and bilaterally at 90 s and 30 min post exercise. Compared to the controls, the Zynamite PX(®) group showed increased basal protein expression of Thr(287)-CaMKIIδ(D) (2-fold, p = 0.007) and Ser(9)-GSK3β (1.3-fold, p = 0.005) and a non-significant increase of total NRF2 (1.7-fold, p = 0.099) and Ser(40)-NRF2 (1.2-fold, p = 0.061). In the controls, there was upregulation with exercise and recovery of total NRF2, catalase, glutathione reductase, and Thr(287)-CaMKIIδ(D) (1.2–2.9-fold, all p < 0.05), which was not observed in the Zynamite PX(®) group. In conclusion, Zynamite PX(®) elicits muscle signaling changes in resting skeletal muscle resembling those described for exercise training and partly abrogates the stress kinases responses to exercise as observed in trained muscles. |
format | Online Article Text |
id | pubmed-10346248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103462482023-07-15 A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle Martinez-Canton, Miriam Galvan-Alvarez, Victor Garcia-Gonzalez, Eduardo Gallego-Selles, Angel Gelabert-Rebato, Miriam Garcia-Perez, Giovanni Santana, Alfredo Lopez-Rios, Laura Vega-Morales, Tanausu Martin-Rincon, Marcos Calbet, Jose A. L. Nutrients Article Zynamite PX(®), a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite(®) + 140 mg quercetin/8 h for 2 days). Then, they performed incremental exercise to exhaustion (IE) followed by occlusion of the circulation in one leg for 60 s. Afterwards, the cuff was released, and a 30 s sprint was performed, followed by 90 s circulatory occlusion (same leg). Vastus lateralis muscle biopsies were obtained at baseline, 20 s after IE (occluded leg) and 10 s after Wingate (occluded leg), and bilaterally at 90 s and 30 min post exercise. Compared to the controls, the Zynamite PX(®) group showed increased basal protein expression of Thr(287)-CaMKIIδ(D) (2-fold, p = 0.007) and Ser(9)-GSK3β (1.3-fold, p = 0.005) and a non-significant increase of total NRF2 (1.7-fold, p = 0.099) and Ser(40)-NRF2 (1.2-fold, p = 0.061). In the controls, there was upregulation with exercise and recovery of total NRF2, catalase, glutathione reductase, and Thr(287)-CaMKIIδ(D) (1.2–2.9-fold, all p < 0.05), which was not observed in the Zynamite PX(®) group. In conclusion, Zynamite PX(®) elicits muscle signaling changes in resting skeletal muscle resembling those described for exercise training and partly abrogates the stress kinases responses to exercise as observed in trained muscles. MDPI 2023-06-23 /pmc/articles/PMC10346248/ /pubmed/37447175 http://dx.doi.org/10.3390/nu15132848 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martinez-Canton, Miriam Galvan-Alvarez, Victor Garcia-Gonzalez, Eduardo Gallego-Selles, Angel Gelabert-Rebato, Miriam Garcia-Perez, Giovanni Santana, Alfredo Lopez-Rios, Laura Vega-Morales, Tanausu Martin-Rincon, Marcos Calbet, Jose A. L. A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle |
title | A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle |
title_full | A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle |
title_fullStr | A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle |
title_full_unstemmed | A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle |
title_short | A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle |
title_sort | mango leaf extract (zynamite(®)) combined with quercetin has exercise-mimetic properties in human skeletal muscle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346248/ https://www.ncbi.nlm.nih.gov/pubmed/37447175 http://dx.doi.org/10.3390/nu15132848 |
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