Cargando…

Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform

Methamphetamine (MAP) is a highly addictive and illegal stimulant drug that has a significant impact on the central nervous system. Its detection in biological and street samples is crucial for various organizations involved in forensic medicine, anti-drug efforts, and clinical diagnosis. In recent...

Descripción completa

Detalles Bibliográficos
Autores principales: Truta, Florina, Drăgan, Ana-Maria, Tertis, Mihaela, Parrilla, Marc, Slosse, Amorn, Van Durme, Filip, de Wael, Karolien, Cristea, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346344/
https://www.ncbi.nlm.nih.gov/pubmed/37448052
http://dx.doi.org/10.3390/s23136193
_version_ 1785073293266518016
author Truta, Florina
Drăgan, Ana-Maria
Tertis, Mihaela
Parrilla, Marc
Slosse, Amorn
Van Durme, Filip
de Wael, Karolien
Cristea, Cecilia
author_facet Truta, Florina
Drăgan, Ana-Maria
Tertis, Mihaela
Parrilla, Marc
Slosse, Amorn
Van Durme, Filip
de Wael, Karolien
Cristea, Cecilia
author_sort Truta, Florina
collection PubMed
description Methamphetamine (MAP) is a highly addictive and illegal stimulant drug that has a significant impact on the central nervous system. Its detection in biological and street samples is crucial for various organizations involved in forensic medicine, anti-drug efforts, and clinical diagnosis. In recent years, nanotechnology and nanomaterials have played a significant role in the development of analytical sensors for MAP detection. In this study, a fast, simple, and cost-effective electrochemical sensor is presented that is used for the sensitive detection of MAP in confiscated street samples with a complex matrix. The optimized screen-printed sensor based on a carbon working electrode modified with graphene demonstrated an excellent limit of detection, good sensitivity, and a wide dynamic range (1–500 μM) for the target illicit drug both for standard solutions and real samples (seized samples, tap water, and wastewater samples). It can detect MAP at concentrations as low as 300 nM in real samples. This limit of detection is suitable for the rapid preliminary screening of suspicious samples in customs, ports, airports, and on the street. Furthermore, the sensor exhibits a good recovery rate, indicating its reliability and repeatability. This quality is crucial for ensuring consistent and accurate results during screening processes.
format Online
Article
Text
id pubmed-10346344
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103463442023-07-15 Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform Truta, Florina Drăgan, Ana-Maria Tertis, Mihaela Parrilla, Marc Slosse, Amorn Van Durme, Filip de Wael, Karolien Cristea, Cecilia Sensors (Basel) Article Methamphetamine (MAP) is a highly addictive and illegal stimulant drug that has a significant impact on the central nervous system. Its detection in biological and street samples is crucial for various organizations involved in forensic medicine, anti-drug efforts, and clinical diagnosis. In recent years, nanotechnology and nanomaterials have played a significant role in the development of analytical sensors for MAP detection. In this study, a fast, simple, and cost-effective electrochemical sensor is presented that is used for the sensitive detection of MAP in confiscated street samples with a complex matrix. The optimized screen-printed sensor based on a carbon working electrode modified with graphene demonstrated an excellent limit of detection, good sensitivity, and a wide dynamic range (1–500 μM) for the target illicit drug both for standard solutions and real samples (seized samples, tap water, and wastewater samples). It can detect MAP at concentrations as low as 300 nM in real samples. This limit of detection is suitable for the rapid preliminary screening of suspicious samples in customs, ports, airports, and on the street. Furthermore, the sensor exhibits a good recovery rate, indicating its reliability and repeatability. This quality is crucial for ensuring consistent and accurate results during screening processes. MDPI 2023-07-06 /pmc/articles/PMC10346344/ /pubmed/37448052 http://dx.doi.org/10.3390/s23136193 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Truta, Florina
Drăgan, Ana-Maria
Tertis, Mihaela
Parrilla, Marc
Slosse, Amorn
Van Durme, Filip
de Wael, Karolien
Cristea, Cecilia
Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform
title Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform
title_full Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform
title_fullStr Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform
title_full_unstemmed Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform
title_short Electrochemical Rapid Detection of Methamphetamine from Confiscated Samples Using a Graphene-Based Printed Platform
title_sort electrochemical rapid detection of methamphetamine from confiscated samples using a graphene-based printed platform
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346344/
https://www.ncbi.nlm.nih.gov/pubmed/37448052
http://dx.doi.org/10.3390/s23136193
work_keys_str_mv AT trutaflorina electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT dragananamaria electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT tertismihaela electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT parrillamarc electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT slosseamorn electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT vandurmefilip electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT dewaelkarolien electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform
AT cristeacecilia electrochemicalrapiddetectionofmethamphetaminefromconfiscatedsamplesusingagraphenebasedprintedplatform