Spatial Multiplexing of Whispering Gallery Mode Sensors

Whispering gallery mode resonators have proven to be robust and sensitive platforms for the trace detection of chemical and/or biological analytes. Conventional approaches using serially addressed resonators face challenges in simultaneous multi-channel (i.e., multi-species) detection. We present an alternative monitoring scheme that allows for the spatial multiplexing of whispering gallery mode resonators with the simultaneous observation of the resonance spectra from each of them. By imaging arrays of microspheres and monitoring the glare spot intensities through image processing routines, resonance spectra from multiple resonators may be simultaneously recorded without interference or confounding effects of serial excitation/detection. We demonstrate our multiplexed imaging approach with bulk refractive index variations and virus–antibody binding.