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Dietary Manipulation of Amino Acids for Cancer Therapy
Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346484/ https://www.ncbi.nlm.nih.gov/pubmed/37447206 http://dx.doi.org/10.3390/nu15132879 |
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author | Jiménez-Alonso, Julio José López-Lázaro, Miguel |
author_facet | Jiménez-Alonso, Julio José López-Lázaro, Miguel |
author_sort | Jiménez-Alonso, Julio José |
collection | PubMed |
description | Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted in or supplemented with the 20 proteinogenic AAs, individually and in combination. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers. |
format | Online Article Text |
id | pubmed-10346484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103464842023-07-15 Dietary Manipulation of Amino Acids for Cancer Therapy Jiménez-Alonso, Julio José López-Lázaro, Miguel Nutrients Review Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted in or supplemented with the 20 proteinogenic AAs, individually and in combination. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers. MDPI 2023-06-25 /pmc/articles/PMC10346484/ /pubmed/37447206 http://dx.doi.org/10.3390/nu15132879 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jiménez-Alonso, Julio José López-Lázaro, Miguel Dietary Manipulation of Amino Acids for Cancer Therapy |
title | Dietary Manipulation of Amino Acids for Cancer Therapy |
title_full | Dietary Manipulation of Amino Acids for Cancer Therapy |
title_fullStr | Dietary Manipulation of Amino Acids for Cancer Therapy |
title_full_unstemmed | Dietary Manipulation of Amino Acids for Cancer Therapy |
title_short | Dietary Manipulation of Amino Acids for Cancer Therapy |
title_sort | dietary manipulation of amino acids for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346484/ https://www.ncbi.nlm.nih.gov/pubmed/37447206 http://dx.doi.org/10.3390/nu15132879 |
work_keys_str_mv | AT jimenezalonsojuliojose dietarymanipulationofaminoacidsforcancertherapy AT lopezlazaromiguel dietarymanipulationofaminoacidsforcancertherapy |