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Dietary Manipulation of Amino Acids for Cancer Therapy

Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environm...

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Autores principales: Jiménez-Alonso, Julio José, López-Lázaro, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346484/
https://www.ncbi.nlm.nih.gov/pubmed/37447206
http://dx.doi.org/10.3390/nu15132879
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author Jiménez-Alonso, Julio José
López-Lázaro, Miguel
author_facet Jiménez-Alonso, Julio José
López-Lázaro, Miguel
author_sort Jiménez-Alonso, Julio José
collection PubMed
description Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted in or supplemented with the 20 proteinogenic AAs, individually and in combination. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers.
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spelling pubmed-103464842023-07-15 Dietary Manipulation of Amino Acids for Cancer Therapy Jiménez-Alonso, Julio José López-Lázaro, Miguel Nutrients Review Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted in or supplemented with the 20 proteinogenic AAs, individually and in combination. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers. MDPI 2023-06-25 /pmc/articles/PMC10346484/ /pubmed/37447206 http://dx.doi.org/10.3390/nu15132879 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiménez-Alonso, Julio José
López-Lázaro, Miguel
Dietary Manipulation of Amino Acids for Cancer Therapy
title Dietary Manipulation of Amino Acids for Cancer Therapy
title_full Dietary Manipulation of Amino Acids for Cancer Therapy
title_fullStr Dietary Manipulation of Amino Acids for Cancer Therapy
title_full_unstemmed Dietary Manipulation of Amino Acids for Cancer Therapy
title_short Dietary Manipulation of Amino Acids for Cancer Therapy
title_sort dietary manipulation of amino acids for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346484/
https://www.ncbi.nlm.nih.gov/pubmed/37447206
http://dx.doi.org/10.3390/nu15132879
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