Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties

X-ray and electron-beam (E-beam) sterilization technologies were assessed to supplement gamma sterilization, the most common radiation technology used today for biopharmaceutical product sterilization. The mechanical properties of a PE/EVOH/PE film were studied using tensile tests and dynamical mech...

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Autores principales: Girard-Perier, Nina, Marque, Sylvain R. A., Dupuy, Nathalie, Krieguer, Blanche, Dorey, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346571/
https://www.ncbi.nlm.nih.gov/pubmed/37447445
http://dx.doi.org/10.3390/polym15132799
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author Girard-Perier, Nina
Marque, Sylvain R. A.
Dupuy, Nathalie
Krieguer, Blanche
Dorey, Samuel
author_facet Girard-Perier, Nina
Marque, Sylvain R. A.
Dupuy, Nathalie
Krieguer, Blanche
Dorey, Samuel
author_sort Girard-Perier, Nina
collection PubMed
description X-ray and electron-beam (E-beam) sterilization technologies were assessed to supplement gamma sterilization, the most common radiation technology used today for biopharmaceutical product sterilization. The mechanical properties of a PE/EVOH/PE film were studied using tensile tests and dynamical mechanical analysis after each irradiation technology (i.e., gamma, electron beam and X-ray irradiations). The effects of each irradiation were compared using two statistical methods. The results indicate that the three irradiation technologies induce no difference in mechanical properties in the investigated dose range for this material.
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spelling pubmed-103465712023-07-15 Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties Girard-Perier, Nina Marque, Sylvain R. A. Dupuy, Nathalie Krieguer, Blanche Dorey, Samuel Polymers (Basel) Article X-ray and electron-beam (E-beam) sterilization technologies were assessed to supplement gamma sterilization, the most common radiation technology used today for biopharmaceutical product sterilization. The mechanical properties of a PE/EVOH/PE film were studied using tensile tests and dynamical mechanical analysis after each irradiation technology (i.e., gamma, electron beam and X-ray irradiations). The effects of each irradiation were compared using two statistical methods. The results indicate that the three irradiation technologies induce no difference in mechanical properties in the investigated dose range for this material. MDPI 2023-06-24 /pmc/articles/PMC10346571/ /pubmed/37447445 http://dx.doi.org/10.3390/polym15132799 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Girard-Perier, Nina
Marque, Sylvain R. A.
Dupuy, Nathalie
Krieguer, Blanche
Dorey, Samuel
Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties
title Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties
title_full Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties
title_fullStr Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties
title_full_unstemmed Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties
title_short Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties
title_sort gamma, e-beam and x-ray irradiations on pe/evoh/pe multilayer film: an industrial point of view regarding the impact on mechanical properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346571/
https://www.ncbi.nlm.nih.gov/pubmed/37447445
http://dx.doi.org/10.3390/polym15132799
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