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A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane

A phosphorylcholine polymer (poly(MPC–co–BMA–co–TSMA), PMBT) was prepared by free radical polymerization and coated on the surface of the polymethylpentene hollow fiber membrane (PMP–HFM). ATR–FTIR and SEM analyses showed that the PMBT polymer containing phosphorylcholine groups was uniformly coated...

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Autores principales: Ye, Feihua, Chen, Zhisheng, Li, Chunsheng, Chen, Junhua, Yi, Guobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346637/
https://www.ncbi.nlm.nih.gov/pubmed/37447527
http://dx.doi.org/10.3390/polym15132881
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author Ye, Feihua
Chen, Zhisheng
Li, Chunsheng
Chen, Junhua
Yi, Guobin
author_facet Ye, Feihua
Chen, Zhisheng
Li, Chunsheng
Chen, Junhua
Yi, Guobin
author_sort Ye, Feihua
collection PubMed
description A phosphorylcholine polymer (poly(MPC–co–BMA–co–TSMA), PMBT) was prepared by free radical polymerization and coated on the surface of the polymethylpentene hollow fiber membrane (PMP–HFM). ATR–FTIR and SEM analyses showed that the PMBT polymer containing phosphorylcholine groups was uniformly coated on the surface of the PMP–HFM. Thermogravimetric analysis showed that the PMBT had the best stability when the molar percentage of MPC monomer in the polymer was 35%. The swelling test and static contact angle test indicated that the coating had excellent hydrophilic properties. The fluorescence test results showed that the coating could resist dissolution with 90% (v/v%) ethanol solution and 1% (w/v%) SDS solution. The PMBT coating was shown to be able to decrease platelet adherence to the surface of the hollow fiber membrane, and lower the risk of blood clotting; it had good blood compatibility in tests of whole blood contact and platelet adhesion. These results show that the PMBT polymer may be coated on the surface of the PMP–HFM, and is helpful for improving the blood compatibility of membrane oxygenation.
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spelling pubmed-103466372023-07-15 A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane Ye, Feihua Chen, Zhisheng Li, Chunsheng Chen, Junhua Yi, Guobin Polymers (Basel) Article A phosphorylcholine polymer (poly(MPC–co–BMA–co–TSMA), PMBT) was prepared by free radical polymerization and coated on the surface of the polymethylpentene hollow fiber membrane (PMP–HFM). ATR–FTIR and SEM analyses showed that the PMBT polymer containing phosphorylcholine groups was uniformly coated on the surface of the PMP–HFM. Thermogravimetric analysis showed that the PMBT had the best stability when the molar percentage of MPC monomer in the polymer was 35%. The swelling test and static contact angle test indicated that the coating had excellent hydrophilic properties. The fluorescence test results showed that the coating could resist dissolution with 90% (v/v%) ethanol solution and 1% (w/v%) SDS solution. The PMBT coating was shown to be able to decrease platelet adherence to the surface of the hollow fiber membrane, and lower the risk of blood clotting; it had good blood compatibility in tests of whole blood contact and platelet adhesion. These results show that the PMBT polymer may be coated on the surface of the PMP–HFM, and is helpful for improving the blood compatibility of membrane oxygenation. MDPI 2023-06-29 /pmc/articles/PMC10346637/ /pubmed/37447527 http://dx.doi.org/10.3390/polym15132881 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ye, Feihua
Chen, Zhisheng
Li, Chunsheng
Chen, Junhua
Yi, Guobin
A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane
title A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane
title_full A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane
title_fullStr A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane
title_full_unstemmed A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane
title_short A Study of the Phosphorylcholine Polymer Coating of a Polymethylpentene Hollow Fiber Membrane
title_sort study of the phosphorylcholine polymer coating of a polymethylpentene hollow fiber membrane
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346637/
https://www.ncbi.nlm.nih.gov/pubmed/37447527
http://dx.doi.org/10.3390/polym15132881
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