Cargando…
The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials
(1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose–response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose–response...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346687/ https://www.ncbi.nlm.nih.gov/pubmed/37447309 http://dx.doi.org/10.3390/nu15132983 |
_version_ | 1785073372144599040 |
---|---|
author | Yu, Tingqing Lu, Kun Cao, Xinyi Xia, Hui Wang, Shaokang Sun, Guiju Chen, Liang Liao, Wang |
author_facet | Yu, Tingqing Lu, Kun Cao, Xinyi Xia, Hui Wang, Shaokang Sun, Guiju Chen, Liang Liao, Wang |
author_sort | Yu, Tingqing |
collection | PubMed |
description | (1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose–response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose–response meta-analysis was performed to explore the effect of the cinnamon intervention on glycolipid metabolism. We conducted a comprehensive database search for literature published before November 2022. Nonlinear models were used for dose–response relationship analysis. (3) Results: We identified that a cinnamon intervention was effective in controlling triglyceride (TG) levels (mean difference = −7.31; 95%CI: −12.37, −2.25, p = 0.005) and low-density lipoprotein cholesterol (LDL-C) levels (mean difference = −6.78; 95%CI: −11.35, −2.22, p = 0.004) in type 2 diabetic patients; however, it also was able to increase high-density lipoprotein cholesterol (HDL-C) levels in patients with type 2 diabetes (mean difference = 1.53; 95%CI: 1.01, 2.05, p < 0.001). However, the cinnamon intervention had no significant effect on the level of fasting blood glucose, glycated hemoglobin (HbA1c), or total cholesterol (TC) levels. We found a significant effect of the cinnamon intervention dose on the TG level (p-nonlinearity = 0.016) and LDL-C (p-nonlinearity = 0.019) in the nonlinear dose–response analysis. In the subgroup analysis, we found a hypoglycemic effect with the cinnamon dose ≤1200 mg (mean difference = −11.1, 95%CI: −14.64, −7.58, p < 0.001). (4) Conclusion: Cinnamon intervention may be beneficial in lowering TG and LDL-C levels while enhancing HDL-C levels, and the dosage of the intervention was an important factor in influencing the TG and LDL-C levels. |
format | Online Article Text |
id | pubmed-10346687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103466872023-07-15 The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials Yu, Tingqing Lu, Kun Cao, Xinyi Xia, Hui Wang, Shaokang Sun, Guiju Chen, Liang Liao, Wang Nutrients Review (1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose–response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose–response meta-analysis was performed to explore the effect of the cinnamon intervention on glycolipid metabolism. We conducted a comprehensive database search for literature published before November 2022. Nonlinear models were used for dose–response relationship analysis. (3) Results: We identified that a cinnamon intervention was effective in controlling triglyceride (TG) levels (mean difference = −7.31; 95%CI: −12.37, −2.25, p = 0.005) and low-density lipoprotein cholesterol (LDL-C) levels (mean difference = −6.78; 95%CI: −11.35, −2.22, p = 0.004) in type 2 diabetic patients; however, it also was able to increase high-density lipoprotein cholesterol (HDL-C) levels in patients with type 2 diabetes (mean difference = 1.53; 95%CI: 1.01, 2.05, p < 0.001). However, the cinnamon intervention had no significant effect on the level of fasting blood glucose, glycated hemoglobin (HbA1c), or total cholesterol (TC) levels. We found a significant effect of the cinnamon intervention dose on the TG level (p-nonlinearity = 0.016) and LDL-C (p-nonlinearity = 0.019) in the nonlinear dose–response analysis. In the subgroup analysis, we found a hypoglycemic effect with the cinnamon dose ≤1200 mg (mean difference = −11.1, 95%CI: −14.64, −7.58, p < 0.001). (4) Conclusion: Cinnamon intervention may be beneficial in lowering TG and LDL-C levels while enhancing HDL-C levels, and the dosage of the intervention was an important factor in influencing the TG and LDL-C levels. MDPI 2023-06-30 /pmc/articles/PMC10346687/ /pubmed/37447309 http://dx.doi.org/10.3390/nu15132983 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yu, Tingqing Lu, Kun Cao, Xinyi Xia, Hui Wang, Shaokang Sun, Guiju Chen, Liang Liao, Wang The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials |
title | The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials |
title_full | The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials |
title_fullStr | The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed | The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials |
title_short | The Effect of Cinnamon on Glycolipid Metabolism: A Dose–Response Meta-Analysis of Randomized Controlled Trials |
title_sort | effect of cinnamon on glycolipid metabolism: a dose–response meta-analysis of randomized controlled trials |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346687/ https://www.ncbi.nlm.nih.gov/pubmed/37447309 http://dx.doi.org/10.3390/nu15132983 |
work_keys_str_mv | AT yutingqing theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT lukun theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT caoxinyi theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT xiahui theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT wangshaokang theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT sunguiju theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT chenliang theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT liaowang theeffectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT yutingqing effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT lukun effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT caoxinyi effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT xiahui effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT wangshaokang effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT sunguiju effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT chenliang effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials AT liaowang effectofcinnamononglycolipidmetabolismadoseresponsemetaanalysisofrandomizedcontrolledtrials |