Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration

This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nano...

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Detalles Bibliográficos
Autores principales: Dresvyanina, Elena N., Tagandurdyyeva, Nurjemal A., Kodolova-Chukhontseva, Vera V., Dobrovol’skaya, Irina P., Kamalov, Almaz M., Nashchekina, Yulia A., Nashchekin, Alexey V., Ivanov, Alexey G., Yukina, Galina Yu., Yudin, Vladimir E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346738/
https://www.ncbi.nlm.nih.gov/pubmed/37447506
http://dx.doi.org/10.3390/polym15132860
Descripción
Sumario:This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nanotubes were investigated in this paper. It was shown that introducing 0.5 wt.% of SWCNT into the composite fibers facilitated the formation of a denser fiber structure, resulting in improved strength (σ = 260 MPa) and elastic (E = 14 GPa) characteristics. Additionally, the composite fibers were found to be biocompatible and did not cause significant inflammation or deformation during in vivo studies. A thin layer of connective tissue formed around the fiber.

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