Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody

INTRODUCTION: Obesity has been linked to vascular dysfunction, cognitive impairment and neurodegenerative diseases. However, experimental models that recapitulate brain pathology in relation to obesity and vascular dysfunction are still lacking. METHODS: In this study we performed the histological a...

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Detalles Bibliográficos
Autores principales: Seidel, Florine, Fluiter, Kees, Kleemann, Robert, Worms, Nicole, van Nieuwkoop, Anita, Caspers, Martien P. M., Grigoriadis, Nikolaos, Kiliaan, Amanda J., Baas, Frank, Michailidou, Iliana, Morrison, Martine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346859/
https://www.ncbi.nlm.nih.gov/pubmed/37457817
http://dx.doi.org/10.3389/fncel.2023.1205261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346859/
https://www.ncbi.nlm.nih.gov/pubmed/37457817
http://dx.doi.org/10.3389/fncel.2023.1205261

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