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The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study

Lifestyle has been linked to the incidence of heart failure, but the underlying biological mechanisms remain unclear. Using the metabolomic, lifestyle, and heart failure data of the UK Biobank, we identified and validated healthy lifestyle-related metabolites in a matched case-control and cohort stu...

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Autores principales: Ma, Yuanyuan, Chu, Maomao, Fu, Zuqiang, Liu, Qian, Liang, Jingjia, Xu, Jin, Weng, Zhenkun, Chen, Xiu, Xu, Cheng, Gu, Aihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346862/
https://www.ncbi.nlm.nih.gov/pubmed/37447260
http://dx.doi.org/10.3390/nu15132934
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author Ma, Yuanyuan
Chu, Maomao
Fu, Zuqiang
Liu, Qian
Liang, Jingjia
Xu, Jin
Weng, Zhenkun
Chen, Xiu
Xu, Cheng
Gu, Aihua
author_facet Ma, Yuanyuan
Chu, Maomao
Fu, Zuqiang
Liu, Qian
Liang, Jingjia
Xu, Jin
Weng, Zhenkun
Chen, Xiu
Xu, Cheng
Gu, Aihua
author_sort Ma, Yuanyuan
collection PubMed
description Lifestyle has been linked to the incidence of heart failure, but the underlying biological mechanisms remain unclear. Using the metabolomic, lifestyle, and heart failure data of the UK Biobank, we identified and validated healthy lifestyle-related metabolites in a matched case-control and cohort study, respectively. We then evaluated the association of healthy lifestyle-related metabolites with heart failure (HF) risk and the added predictivity of these healthy lifestyle-associated metabolites for HF. Of 161 metabolites, 8 were identified to be significantly related to healthy lifestyle. Notably, omega-3 fatty acids and docosahexaenoic acid (DHA) positively associated with a healthy lifestyle score (HLS) and exhibited a negative association with heart failure risk. Conversely, creatinine negatively associated with a HLS, but was positively correlated with the risk of HF. Adding these three metabolites to the classical risk factor prediction model, the prediction accuracy of heart failure incidence can be improved as assessed by the C-statistic (increasing from 0.806 [95% CI, 0.796–0.816] to 0.844 [95% CI, 0.834–0.854], p-value < 0.001). A healthy lifestyle is associated with significant metabolic alterations, among which metabolites related to healthy lifestyle may be critical for the relationship between healthy lifestyle and HF. Healthy lifestyle-related metabolites might enhance HF prediction, but additional validation studies are necessary.
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spelling pubmed-103468622023-07-15 The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study Ma, Yuanyuan Chu, Maomao Fu, Zuqiang Liu, Qian Liang, Jingjia Xu, Jin Weng, Zhenkun Chen, Xiu Xu, Cheng Gu, Aihua Nutrients Article Lifestyle has been linked to the incidence of heart failure, but the underlying biological mechanisms remain unclear. Using the metabolomic, lifestyle, and heart failure data of the UK Biobank, we identified and validated healthy lifestyle-related metabolites in a matched case-control and cohort study, respectively. We then evaluated the association of healthy lifestyle-related metabolites with heart failure (HF) risk and the added predictivity of these healthy lifestyle-associated metabolites for HF. Of 161 metabolites, 8 were identified to be significantly related to healthy lifestyle. Notably, omega-3 fatty acids and docosahexaenoic acid (DHA) positively associated with a healthy lifestyle score (HLS) and exhibited a negative association with heart failure risk. Conversely, creatinine negatively associated with a HLS, but was positively correlated with the risk of HF. Adding these three metabolites to the classical risk factor prediction model, the prediction accuracy of heart failure incidence can be improved as assessed by the C-statistic (increasing from 0.806 [95% CI, 0.796–0.816] to 0.844 [95% CI, 0.834–0.854], p-value < 0.001). A healthy lifestyle is associated with significant metabolic alterations, among which metabolites related to healthy lifestyle may be critical for the relationship between healthy lifestyle and HF. Healthy lifestyle-related metabolites might enhance HF prediction, but additional validation studies are necessary. MDPI 2023-06-28 /pmc/articles/PMC10346862/ /pubmed/37447260 http://dx.doi.org/10.3390/nu15132934 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Yuanyuan
Chu, Maomao
Fu, Zuqiang
Liu, Qian
Liang, Jingjia
Xu, Jin
Weng, Zhenkun
Chen, Xiu
Xu, Cheng
Gu, Aihua
The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study
title The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study
title_full The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study
title_fullStr The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study
title_full_unstemmed The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study
title_short The Association of Metabolomic Profiles of a Healthy Lifestyle with Heart Failure Risk in a Prospective Study
title_sort association of metabolomic profiles of a healthy lifestyle with heart failure risk in a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346862/
https://www.ncbi.nlm.nih.gov/pubmed/37447260
http://dx.doi.org/10.3390/nu15132934
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