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Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy

Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for...

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Autores principales: Herdiana, Yedi, Husni, Patihul, Nurhasanah, Siti, Shamsuddin, Shaharum, Wathoni, Nasrul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347152/
https://www.ncbi.nlm.nih.gov/pubmed/37447598
http://dx.doi.org/10.3390/polym15132953
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author Herdiana, Yedi
Husni, Patihul
Nurhasanah, Siti
Shamsuddin, Shaharum
Wathoni, Nasrul
author_facet Herdiana, Yedi
Husni, Patihul
Nurhasanah, Siti
Shamsuddin, Shaharum
Wathoni, Nasrul
author_sort Herdiana, Yedi
collection PubMed
description Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body’s internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs.
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spelling pubmed-103471522023-07-15 Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy Herdiana, Yedi Husni, Patihul Nurhasanah, Siti Shamsuddin, Shaharum Wathoni, Nasrul Polymers (Basel) Review Breast cancer is a major cause of death globally, accounting for around 13% of all deaths. Chemotherapy, the common treatment for cancer, can have side effects that lead to the production of reactive oxygen species (ROS) and an increase in oxidative stress in the body. Antioxidants are important for maintaining the health of cells and helping the immune system function properly. They play a crucial role in balancing the body’s internal environment. Using natural antioxidants is an alternative to mitigate the harmful effects of oxidative stress. However, around 80% of natural antioxidants have limited effectiveness when taken orally because they do not dissolve well in water or other solvents. This poor solubility affects their ability to be absorbed by the body and limits their bioavailability. One strategy that has been considered is to increase their water solubility to increase their oral bioavailability. Chitosan-based nanoparticle (CSNP) systems have been extensively explored due to their reliability and simpler synthesis routes. This review focuses on the various methods of chitosan-based nanoformulation for developing effective oral dosage forms for natural antioxidants based on the pharmacokinetics and pharmacodynamics properties. Chitosan (CS) could be a model, because of its wide use in polymeric NPs research, thus providing a better understanding of the role of vehicles that carry natural antioxidants in maintaining the stability and enhancing the performance of cancer drugs. MDPI 2023-07-05 /pmc/articles/PMC10347152/ /pubmed/37447598 http://dx.doi.org/10.3390/polym15132953 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Herdiana, Yedi
Husni, Patihul
Nurhasanah, Siti
Shamsuddin, Shaharum
Wathoni, Nasrul
Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy
title Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy
title_full Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy
title_fullStr Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy
title_full_unstemmed Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy
title_short Chitosan-Based Nano Systems for Natural Antioxidants in Breast Cancer Therapy
title_sort chitosan-based nano systems for natural antioxidants in breast cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347152/
https://www.ncbi.nlm.nih.gov/pubmed/37447598
http://dx.doi.org/10.3390/polym15132953
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