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Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations

Recent research supports previous contentions that encapsulating vitamins and minerals with liposomes help improve overall bioavailability. This study examined whether ingesting a liposomal multivitamin and mineral supplement (MVM) differentially affects the appearance and/or clearance of vitamins a...

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Autores principales: Ko, Joungbo, Yoo, Choongsung, Xing, Dante, Gonzalez, Drew E., Jenkins, Victoria, Dickerson, Broderick, Leonard, Megan, Nottingham, Kay, Kendra, Jacob, Sowinski, Ryan, Rasmussen, Christopher J., Kreider, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347199/
https://www.ncbi.nlm.nih.gov/pubmed/37447400
http://dx.doi.org/10.3390/nu15133073
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author Ko, Joungbo
Yoo, Choongsung
Xing, Dante
Gonzalez, Drew E.
Jenkins, Victoria
Dickerson, Broderick
Leonard, Megan
Nottingham, Kay
Kendra, Jacob
Sowinski, Ryan
Rasmussen, Christopher J.
Kreider, Richard B.
author_facet Ko, Joungbo
Yoo, Choongsung
Xing, Dante
Gonzalez, Drew E.
Jenkins, Victoria
Dickerson, Broderick
Leonard, Megan
Nottingham, Kay
Kendra, Jacob
Sowinski, Ryan
Rasmussen, Christopher J.
Kreider, Richard B.
author_sort Ko, Joungbo
collection PubMed
description Recent research supports previous contentions that encapsulating vitamins and minerals with liposomes help improve overall bioavailability. This study examined whether ingesting a liposomal multivitamin and mineral supplement (MVM) differentially affects the appearance and/or clearance of vitamins and minerals in the blood compared to a non-liposomal MVM supplement. In a double-blind, randomized, and counterbalanced manner, 34 healthy men and women fasted for 12 h. Then, they ingested a non-liposomal (NL) or liposomal (L) MVM supplement and a standardized snack. Venous blood samples were obtained at 0, 2, 4, and 6 h after MVM ingestion and analyzed for a panel of vitamins and minerals. Plasma levels of vitamins and minerals and mean changes from baseline with 95% confidence intervals (CIs) were analyzed using general linear model statistics with repeated measures. The observed values were also entered into pharmacokinetic analysis software and analyzed through univariate analysis of variance with repeated measure contrasts. The results revealed an overall treatment x time interaction effect among the vitamins and minerals evaluated (p = 0.051, [Formula: see text] = 0.054, moderate effect). Differences between treatments were also observed in volume distribution area (vitamin E, iron), median residence time (vitamin E, iron), volume distribution area (iron), volume of distribution steady state (vitamin A, E, iron), clearance rates (vitamin A, E), elimination phase half-life (vitamin E, iron), distribution/absorption phase intercept (vitamin A), and distribution/absorption phase slope and rate (vitamin C, calcium). Vitamin volume distribution was lower with liposomal MVM ingestion than non-liposomal MVM sources, suggesting greater clearance and absorption since similar amounts of vitamins and minerals were ingested. These findings indicate that coating a MVM with liposomes affects individual nutrient pharmacokinetic profiles. Additional research should evaluate how long-term supplementation of liposomal MVM supplements may affect vitamin and mineral status, nutrient function, and/or health outcomes.
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spelling pubmed-103471992023-07-15 Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations Ko, Joungbo Yoo, Choongsung Xing, Dante Gonzalez, Drew E. Jenkins, Victoria Dickerson, Broderick Leonard, Megan Nottingham, Kay Kendra, Jacob Sowinski, Ryan Rasmussen, Christopher J. Kreider, Richard B. Nutrients Article Recent research supports previous contentions that encapsulating vitamins and minerals with liposomes help improve overall bioavailability. This study examined whether ingesting a liposomal multivitamin and mineral supplement (MVM) differentially affects the appearance and/or clearance of vitamins and minerals in the blood compared to a non-liposomal MVM supplement. In a double-blind, randomized, and counterbalanced manner, 34 healthy men and women fasted for 12 h. Then, they ingested a non-liposomal (NL) or liposomal (L) MVM supplement and a standardized snack. Venous blood samples were obtained at 0, 2, 4, and 6 h after MVM ingestion and analyzed for a panel of vitamins and minerals. Plasma levels of vitamins and minerals and mean changes from baseline with 95% confidence intervals (CIs) were analyzed using general linear model statistics with repeated measures. The observed values were also entered into pharmacokinetic analysis software and analyzed through univariate analysis of variance with repeated measure contrasts. The results revealed an overall treatment x time interaction effect among the vitamins and minerals evaluated (p = 0.051, [Formula: see text] = 0.054, moderate effect). Differences between treatments were also observed in volume distribution area (vitamin E, iron), median residence time (vitamin E, iron), volume distribution area (iron), volume of distribution steady state (vitamin A, E, iron), clearance rates (vitamin A, E), elimination phase half-life (vitamin E, iron), distribution/absorption phase intercept (vitamin A), and distribution/absorption phase slope and rate (vitamin C, calcium). Vitamin volume distribution was lower with liposomal MVM ingestion than non-liposomal MVM sources, suggesting greater clearance and absorption since similar amounts of vitamins and minerals were ingested. These findings indicate that coating a MVM with liposomes affects individual nutrient pharmacokinetic profiles. Additional research should evaluate how long-term supplementation of liposomal MVM supplements may affect vitamin and mineral status, nutrient function, and/or health outcomes. MDPI 2023-07-07 /pmc/articles/PMC10347199/ /pubmed/37447400 http://dx.doi.org/10.3390/nu15133073 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Joungbo
Yoo, Choongsung
Xing, Dante
Gonzalez, Drew E.
Jenkins, Victoria
Dickerson, Broderick
Leonard, Megan
Nottingham, Kay
Kendra, Jacob
Sowinski, Ryan
Rasmussen, Christopher J.
Kreider, Richard B.
Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations
title Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations
title_full Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations
title_fullStr Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations
title_full_unstemmed Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations
title_short Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations
title_sort pharmacokinetic analyses of liposomal and non-liposomal multivitamin/mineral formulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347199/
https://www.ncbi.nlm.nih.gov/pubmed/37447400
http://dx.doi.org/10.3390/nu15133073
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