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No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study

BACKGROUND: Numerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian rand...

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Autores principales: Gao, Ya-fang, Jin, Tian-yu, Chen, Yan, Ding, Ya-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347408/
https://www.ncbi.nlm.nih.gov/pubmed/37456823
http://dx.doi.org/10.3389/fcvm.2023.1071574
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author Gao, Ya-fang
Jin, Tian-yu
Chen, Yan
Ding, Ya-hui
author_facet Gao, Ya-fang
Jin, Tian-yu
Chen, Yan
Ding, Ya-hui
author_sort Gao, Ya-fang
collection PubMed
description BACKGROUND: Numerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian randomization (MR) analysis to investigate the causal genetic relationships between AF and VaD. METHODS: The bidirectional MR analysis was conducted to explore the causal relationships between exposure and disease. We applied a series of quality assessments to select significantly and independently single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases. Three methods [Inverse variance weighted method (IVW), MR-Egger method, and weighted median (WM)method] were used to derive MR estimates. In order to ensure reliable MR results, sensitivity analyses were performed to evaluate the horizontal pleiotropy and heterogeneity. RESULTS: Our MR analyses revealed no significant genetic relationships between AF and the risk of VaD (IVW: OR =  1.10, 95%CI = 0.95–1.28, P = 0.20). In the reverse direction analysis, there was no evidence to support a significant genetic relationship of VaD with AF risk (IVW: OR =  1.00, 95% CI = 0.99–1.01, P = 0.52). Consistent results were obtained using different MR methods. Sensitivity analyses suggested no significant horizontal pleiotropy and heterogeneity in the study. CONCLUSION: This MR analysis did not provide evidence to support the causal genetic relationships between AF on VaD risk and the causal effect of VaD on AF risk.
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spelling pubmed-103474082023-07-15 No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study Gao, Ya-fang Jin, Tian-yu Chen, Yan Ding, Ya-hui Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Numerous observational studies have suggested that atrial fibrillation (AF) was associated with an increased risk of vascular dementia (VaD). However, the causal genetic relationships between AF and VaD remains unclear. To evaluate the effect of AF on VaD, we performed the Mendelian randomization (MR) analysis to investigate the causal genetic relationships between AF and VaD. METHODS: The bidirectional MR analysis was conducted to explore the causal relationships between exposure and disease. We applied a series of quality assessments to select significantly and independently single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases. Three methods [Inverse variance weighted method (IVW), MR-Egger method, and weighted median (WM)method] were used to derive MR estimates. In order to ensure reliable MR results, sensitivity analyses were performed to evaluate the horizontal pleiotropy and heterogeneity. RESULTS: Our MR analyses revealed no significant genetic relationships between AF and the risk of VaD (IVW: OR =  1.10, 95%CI = 0.95–1.28, P = 0.20). In the reverse direction analysis, there was no evidence to support a significant genetic relationship of VaD with AF risk (IVW: OR =  1.00, 95% CI = 0.99–1.01, P = 0.52). Consistent results were obtained using different MR methods. Sensitivity analyses suggested no significant horizontal pleiotropy and heterogeneity in the study. CONCLUSION: This MR analysis did not provide evidence to support the causal genetic relationships between AF on VaD risk and the causal effect of VaD on AF risk. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10347408/ /pubmed/37456823 http://dx.doi.org/10.3389/fcvm.2023.1071574 Text en © 2023 Gao, Jin, Chen and Ding. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Gao, Ya-fang
Jin, Tian-yu
Chen, Yan
Ding, Ya-hui
No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
title No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
title_full No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
title_fullStr No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
title_full_unstemmed No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
title_short No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study
title_sort no causal genetic relationships between atrial fibrillation and vascular dementia: a bidirectional mendelian randomization study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347408/
https://www.ncbi.nlm.nih.gov/pubmed/37456823
http://dx.doi.org/10.3389/fcvm.2023.1071574
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