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Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study

INTRODUCTION: To investigate the associations of a lifestyle score with various cardiovascular risk markers, indicators for fatty liver disease as well as MRI-determined total, subcutaneous and visceral adipose tissue mass in adults with new-onset diabetes. RESEARCH DESIGN AND METHODS: This cross-se...

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Autores principales: Baechle, Christina, Lang, Alexander, Strassburger, Klaus, Kuss, Oliver, Burkart, Volker, Szendroedi, Julia, Müssig, Karsten, Weber, Katharina Susanne, Schrauwen-Hinderling, Vera, Herder, Christian, Roden, Michael, Schlesinger, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347481/
https://www.ncbi.nlm.nih.gov/pubmed/37433698
http://dx.doi.org/10.1136/bmjdrc-2023-003469
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author Baechle, Christina
Lang, Alexander
Strassburger, Klaus
Kuss, Oliver
Burkart, Volker
Szendroedi, Julia
Müssig, Karsten
Weber, Katharina Susanne
Schrauwen-Hinderling, Vera
Herder, Christian
Roden, Michael
Schlesinger, Sabrina
author_facet Baechle, Christina
Lang, Alexander
Strassburger, Klaus
Kuss, Oliver
Burkart, Volker
Szendroedi, Julia
Müssig, Karsten
Weber, Katharina Susanne
Schrauwen-Hinderling, Vera
Herder, Christian
Roden, Michael
Schlesinger, Sabrina
author_sort Baechle, Christina
collection PubMed
description INTRODUCTION: To investigate the associations of a lifestyle score with various cardiovascular risk markers, indicators for fatty liver disease as well as MRI-determined total, subcutaneous and visceral adipose tissue mass in adults with new-onset diabetes. RESEARCH DESIGN AND METHODS: This cross-sectional analysis included 196 individuals with type 1 (median age: 35 years; median body mass index (BMI): 24 kg/m²) and 272 with type 2 diabetes (median age: 53 years; median BMI: 31 kg/m²) from the German Diabetes Study. A healthy lifestyle score was generated based on healthy diet, moderate alcohol consumption, recreational activity, non-smoking and non-obese BMI. These factors were summed to form a score ranging from 0 to 5. Multivariable linear and non-linear regression models were used. RESULTS: In total, 8.1% of the individuals adhered to none or one, 17.7% to two, 29.7% to three, 26.7% to four, and 17.7% to all five favorable lifestyle factors. High compared with low adherence to the lifestyle score was associated with more favorable outcome measures, including triglycerides (β (95% CI) −49.1 mg/dL (−76.7; −21.4)), low-density lipoprotein (−16.7 mg/dL (−31.3; −2.0)), and high-density lipoprotein cholesterol (13.5 mg/dL (7.6; 19.4)), glycated hemoglobin (−0.5% (−0.8%; −0.1%)), high-sensitivity C reactive protein (−0.4 mg/dL (−0.6; −0.2)), as well as lower hepatic fat content (−8.3% (−11.9%; −4.7%)), and visceral adipose tissue mass (−1.8 dm³ (−2.9; −0.7)). The dose–response analyses showed that adherence to every additional healthy lifestyle factor was associated with more beneficial risk profiles. CONCLUSIONS: Adherence to each additional healthy lifestyle factor was beneficially associated with cardiovascular risk markers, indicators of fatty liver disease and adipose tissue mass. Strongest associations were observed for adherence to all healthy lifestyle factors in combination. TRIAL REGISTRATION NUMBER: NCT01055093.
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spelling pubmed-103474812023-07-15 Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study Baechle, Christina Lang, Alexander Strassburger, Klaus Kuss, Oliver Burkart, Volker Szendroedi, Julia Müssig, Karsten Weber, Katharina Susanne Schrauwen-Hinderling, Vera Herder, Christian Roden, Michael Schlesinger, Sabrina BMJ Open Diabetes Res Care Clinical care/Education/Nutrition INTRODUCTION: To investigate the associations of a lifestyle score with various cardiovascular risk markers, indicators for fatty liver disease as well as MRI-determined total, subcutaneous and visceral adipose tissue mass in adults with new-onset diabetes. RESEARCH DESIGN AND METHODS: This cross-sectional analysis included 196 individuals with type 1 (median age: 35 years; median body mass index (BMI): 24 kg/m²) and 272 with type 2 diabetes (median age: 53 years; median BMI: 31 kg/m²) from the German Diabetes Study. A healthy lifestyle score was generated based on healthy diet, moderate alcohol consumption, recreational activity, non-smoking and non-obese BMI. These factors were summed to form a score ranging from 0 to 5. Multivariable linear and non-linear regression models were used. RESULTS: In total, 8.1% of the individuals adhered to none or one, 17.7% to two, 29.7% to three, 26.7% to four, and 17.7% to all five favorable lifestyle factors. High compared with low adherence to the lifestyle score was associated with more favorable outcome measures, including triglycerides (β (95% CI) −49.1 mg/dL (−76.7; −21.4)), low-density lipoprotein (−16.7 mg/dL (−31.3; −2.0)), and high-density lipoprotein cholesterol (13.5 mg/dL (7.6; 19.4)), glycated hemoglobin (−0.5% (−0.8%; −0.1%)), high-sensitivity C reactive protein (−0.4 mg/dL (−0.6; −0.2)), as well as lower hepatic fat content (−8.3% (−11.9%; −4.7%)), and visceral adipose tissue mass (−1.8 dm³ (−2.9; −0.7)). The dose–response analyses showed that adherence to every additional healthy lifestyle factor was associated with more beneficial risk profiles. CONCLUSIONS: Adherence to each additional healthy lifestyle factor was beneficially associated with cardiovascular risk markers, indicators of fatty liver disease and adipose tissue mass. Strongest associations were observed for adherence to all healthy lifestyle factors in combination. TRIAL REGISTRATION NUMBER: NCT01055093. BMJ Publishing Group 2023-07-11 /pmc/articles/PMC10347481/ /pubmed/37433698 http://dx.doi.org/10.1136/bmjdrc-2023-003469 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Clinical care/Education/Nutrition
Baechle, Christina
Lang, Alexander
Strassburger, Klaus
Kuss, Oliver
Burkart, Volker
Szendroedi, Julia
Müssig, Karsten
Weber, Katharina Susanne
Schrauwen-Hinderling, Vera
Herder, Christian
Roden, Michael
Schlesinger, Sabrina
Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
title Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
title_full Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
title_fullStr Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
title_full_unstemmed Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
title_short Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
title_sort association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
topic Clinical care/Education/Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347481/
https://www.ncbi.nlm.nih.gov/pubmed/37433698
http://dx.doi.org/10.1136/bmjdrc-2023-003469
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