Cargando…

The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer

BACKGROUND: Previous studies have suggested that the ratios of immune-inflammatory cells could serve as prognostic indicators in ovarian cancer. However, which of these is the superior prognostic indicator in ovarian cancer remains unknown. In addition, studies on the prognostic value of the platele...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Qian, Xu, Song-Xiao, Wu, Jun-Zhou, Ling, Lin, Wang, Sheng, Shu, Xin-Hua, Ying, Dan-Ni, Pei, Wang-Wei, Wu, Yu-Chen, Sun, Su-Fang, Zhang, Yi-Ning, Zhou, Si-Hang, Shao, Zhu-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347525/
https://www.ncbi.nlm.nih.gov/pubmed/37457691
http://dx.doi.org/10.3389/fimmu.2023.1177403
_version_ 1785073566341922816
author Song, Qian
Xu, Song-Xiao
Wu, Jun-Zhou
Ling, Lin
Wang, Sheng
Shu, Xin-Hua
Ying, Dan-Ni
Pei, Wang-Wei
Wu, Yu-Chen
Sun, Su-Fang
Zhang, Yi-Ning
Zhou, Si-Hang
Shao, Zhu-Yan
author_facet Song, Qian
Xu, Song-Xiao
Wu, Jun-Zhou
Ling, Lin
Wang, Sheng
Shu, Xin-Hua
Ying, Dan-Ni
Pei, Wang-Wei
Wu, Yu-Chen
Sun, Su-Fang
Zhang, Yi-Ning
Zhou, Si-Hang
Shao, Zhu-Yan
author_sort Song, Qian
collection PubMed
description BACKGROUND: Previous studies have suggested that the ratios of immune-inflammatory cells could serve as prognostic indicators in ovarian cancer. However, which of these is the superior prognostic indicator in ovarian cancer remains unknown. In addition, studies on the prognostic value of the platelet to neutrophil ratio (PNR) in ovarian cancer are still limited. METHODS: A cohort of 991 ovarian cancer patients was analyzed in the present study. Receiver operator characteristic (ROC) curves were utilized to choose the optimal cut-off values of inflammatory biomarkers such as neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and PNR. The correlation of inflammatory biomarkers with overall survival (OS) and relapse-free survival (RFS) was investigated by Kaplan-Meier methods and log-rank test, followed by Cox regression analyses. RESULTS: Kaplan-Meier curves suggested that LMR<3.39, PLR≥181.46, and PNR≥49.20 had obvious associations with worse RFS (P<0.001, P=0.018, P<0.001). Multivariate analysis suggested that LMR (≥3.39 vs. <3.39) (P=0.042, HR=0.810, 95% CI=0.661-0.992) and PNR (≥49.20 vs. <49.20) (P=0.004, HR=1.351, 95% CI=1.103-1.656) were independent prognostic indicators of poor RFS. In addition, Kaplan-Meier curves indicated that PLR≥182.23 was significantly correlated with worse OS (P=0.039). CONCLUSION: Taken together, PNR and LMR are superior prognostic indicators compared with NLR, PLR, and SII in patients with ovarian cancer.
format Online
Article
Text
id pubmed-10347525
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103475252023-07-15 The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer Song, Qian Xu, Song-Xiao Wu, Jun-Zhou Ling, Lin Wang, Sheng Shu, Xin-Hua Ying, Dan-Ni Pei, Wang-Wei Wu, Yu-Chen Sun, Su-Fang Zhang, Yi-Ning Zhou, Si-Hang Shao, Zhu-Yan Front Immunol Immunology BACKGROUND: Previous studies have suggested that the ratios of immune-inflammatory cells could serve as prognostic indicators in ovarian cancer. However, which of these is the superior prognostic indicator in ovarian cancer remains unknown. In addition, studies on the prognostic value of the platelet to neutrophil ratio (PNR) in ovarian cancer are still limited. METHODS: A cohort of 991 ovarian cancer patients was analyzed in the present study. Receiver operator characteristic (ROC) curves were utilized to choose the optimal cut-off values of inflammatory biomarkers such as neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and PNR. The correlation of inflammatory biomarkers with overall survival (OS) and relapse-free survival (RFS) was investigated by Kaplan-Meier methods and log-rank test, followed by Cox regression analyses. RESULTS: Kaplan-Meier curves suggested that LMR<3.39, PLR≥181.46, and PNR≥49.20 had obvious associations with worse RFS (P<0.001, P=0.018, P<0.001). Multivariate analysis suggested that LMR (≥3.39 vs. <3.39) (P=0.042, HR=0.810, 95% CI=0.661-0.992) and PNR (≥49.20 vs. <49.20) (P=0.004, HR=1.351, 95% CI=1.103-1.656) were independent prognostic indicators of poor RFS. In addition, Kaplan-Meier curves indicated that PLR≥182.23 was significantly correlated with worse OS (P=0.039). CONCLUSION: Taken together, PNR and LMR are superior prognostic indicators compared with NLR, PLR, and SII in patients with ovarian cancer. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10347525/ /pubmed/37457691 http://dx.doi.org/10.3389/fimmu.2023.1177403 Text en Copyright © 2023 Song, Xu, Wu, Ling, Wang, Shu, Ying, Pei, Wu, Sun, Zhang, Zhou and Shao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Song, Qian
Xu, Song-Xiao
Wu, Jun-Zhou
Ling, Lin
Wang, Sheng
Shu, Xin-Hua
Ying, Dan-Ni
Pei, Wang-Wei
Wu, Yu-Chen
Sun, Su-Fang
Zhang, Yi-Ning
Zhou, Si-Hang
Shao, Zhu-Yan
The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
title The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
title_full The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
title_fullStr The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
title_full_unstemmed The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
title_short The preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
title_sort preoperative platelet to neutrophil ratio and lymphocyte to monocyte ratio are superior prognostic indicators compared with other inflammatory biomarkers in ovarian cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347525/
https://www.ncbi.nlm.nih.gov/pubmed/37457691
http://dx.doi.org/10.3389/fimmu.2023.1177403
work_keys_str_mv AT songqian thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT xusongxiao thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT wujunzhou thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT linglin thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT wangsheng thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT shuxinhua thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT yingdanni thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT peiwangwei thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT wuyuchen thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT sunsufang thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT zhangyining thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT zhousihang thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT shaozhuyan thepreoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT songqian preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT xusongxiao preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT wujunzhou preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT linglin preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT wangsheng preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT shuxinhua preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT yingdanni preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT peiwangwei preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT wuyuchen preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT sunsufang preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT zhangyining preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT zhousihang preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer
AT shaozhuyan preoperativeplatelettoneutrophilratioandlymphocytetomonocyteratioaresuperiorprognosticindicatorscomparedwithotherinflammatorybiomarkersinovariancancer