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Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation

BACKGROUND: A growing body of literature has implicated the left dorsolateral prefrontal cortex (DLPFC) in the online monitoring of vocal production through auditory feedback. Specifically, disruption of or damage to the left DLPFC leads to exaggerated compensatory vocal responses to altered auditor...

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Autores principales: Chang, Yichen, Peng, Danhua, Zhao, Yan, Chen, Xi, Li, Jingting, Wu, Xiuqin, Liu, Peng, Liu, Hanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347532/
https://www.ncbi.nlm.nih.gov/pubmed/37457017
http://dx.doi.org/10.3389/fnins.2023.1208581
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author Chang, Yichen
Peng, Danhua
Zhao, Yan
Chen, Xi
Li, Jingting
Wu, Xiuqin
Liu, Peng
Liu, Hanjun
author_facet Chang, Yichen
Peng, Danhua
Zhao, Yan
Chen, Xi
Li, Jingting
Wu, Xiuqin
Liu, Peng
Liu, Hanjun
author_sort Chang, Yichen
collection PubMed
description BACKGROUND: A growing body of literature has implicated the left dorsolateral prefrontal cortex (DLPFC) in the online monitoring of vocal production through auditory feedback. Specifically, disruption of or damage to the left DLPFC leads to exaggerated compensatory vocal responses to altered auditory feedback. It is conceivable that enhancing the cortical excitability of the left DLPFC may produce inhibitory influences on vocal feedback control by reducing vocal compensations. METHODS: We used anodal transcranial direct current stimulation (a-tDCS) to modulate cortical excitability of the left DLPFC and examined its effects on auditory-motor integration for vocal pitch regulation. Seventeen healthy young adults vocalized vowel sounds while hearing their voice pseudo-randomly pitch-shifted by ±50 or ±200 cents, either during (online) or after (offline) receiving active or sham a-tDCS over the left DLPFC. RESULTS: Active a-tDCS over the left DLPFC led to significantly smaller peak magnitudes and shorter peak times of vocal compensations for pitch perturbations than sham stimulation. In addition, this effect was consistent regardless of the timing of a-tDCS (online or offline stimulation) and the size and direction of the pitch perturbation. CONCLUSION: These findings provide the first causal evidence that a-tDCS over the left DLPFC can facilitate auditory-motor integration for compensatory adjustment to errors in vocal output. Reduced and accelerated vocal compensations caused by a-tDCS over left DLPFC support the hypothesis of a top–down neural mechanism that exerts inhibitory control over vocal motor behavior through auditory feedback.
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spelling pubmed-103475322023-07-15 Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation Chang, Yichen Peng, Danhua Zhao, Yan Chen, Xi Li, Jingting Wu, Xiuqin Liu, Peng Liu, Hanjun Front Neurosci Neuroscience BACKGROUND: A growing body of literature has implicated the left dorsolateral prefrontal cortex (DLPFC) in the online monitoring of vocal production through auditory feedback. Specifically, disruption of or damage to the left DLPFC leads to exaggerated compensatory vocal responses to altered auditory feedback. It is conceivable that enhancing the cortical excitability of the left DLPFC may produce inhibitory influences on vocal feedback control by reducing vocal compensations. METHODS: We used anodal transcranial direct current stimulation (a-tDCS) to modulate cortical excitability of the left DLPFC and examined its effects on auditory-motor integration for vocal pitch regulation. Seventeen healthy young adults vocalized vowel sounds while hearing their voice pseudo-randomly pitch-shifted by ±50 or ±200 cents, either during (online) or after (offline) receiving active or sham a-tDCS over the left DLPFC. RESULTS: Active a-tDCS over the left DLPFC led to significantly smaller peak magnitudes and shorter peak times of vocal compensations for pitch perturbations than sham stimulation. In addition, this effect was consistent regardless of the timing of a-tDCS (online or offline stimulation) and the size and direction of the pitch perturbation. CONCLUSION: These findings provide the first causal evidence that a-tDCS over the left DLPFC can facilitate auditory-motor integration for compensatory adjustment to errors in vocal output. Reduced and accelerated vocal compensations caused by a-tDCS over left DLPFC support the hypothesis of a top–down neural mechanism that exerts inhibitory control over vocal motor behavior through auditory feedback. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10347532/ /pubmed/37457017 http://dx.doi.org/10.3389/fnins.2023.1208581 Text en Copyright © 2023 Chang, Peng, Zhao, Chen, Li, Wu, Liu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chang, Yichen
Peng, Danhua
Zhao, Yan
Chen, Xi
Li, Jingting
Wu, Xiuqin
Liu, Peng
Liu, Hanjun
Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
title Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
title_full Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
title_fullStr Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
title_full_unstemmed Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
title_short Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
title_sort transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347532/
https://www.ncbi.nlm.nih.gov/pubmed/37457017
http://dx.doi.org/10.3389/fnins.2023.1208581
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