CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca(2+)-handling abnormalities: implication in cardiac arrhythmias

BACKGROUND: Sustained, chronic activation of β-adrenergic receptor (β-AR) signaling leads to cardiac arrhythmias, with exchange proteins directly activated by cAMP (Epac1 and Epac2) as key mediators. This study aimed to evaluate whether CD44, a transmembrane receptor mediating various cellular respo...

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Detalles Bibliográficos
Autores principales: Chan, Yi-Hsin, Tsai, Feng-Chun, Chang, Gwo-Jyh, Lai, Ying-Ju, Chang, Shang-Hung, Chen, Wei-Jan, Yeh, Yung-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347873/
https://www.ncbi.nlm.nih.gov/pubmed/37452346
http://dx.doi.org/10.1186/s12929-023-00944-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347873/
https://www.ncbi.nlm.nih.gov/pubmed/37452346
http://dx.doi.org/10.1186/s12929-023-00944-0

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