A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023

An outbreak of Ralstonia mannitolilytica bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated wit...

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Detalles Bibliográficos
Autores principales: Fabricci, Massimiliano, Trinca, Anaïs, Talotti, Luca, Busetti, Marina, Fotakis, Emmanouil Alexandros, Merakou, Christina, Koncan, Raffaella, Ghiotti, Annachiara, Negri, Camilla, Di Maso, Vittorio, Bosco, Manuela, Antonelli, Alberto, Coppi, Marco, Rossolini, Gian Maria, Giuliani, Claudia, Scarpis, Enrico, Gregoretti, Barbara, Licastro, Danilo, Luzzati, Roberto, Costantino, Venera, Barbone, Fabio, Bedina, Elisa, Bottacin, Tania, Cara, Alice, Cipriani, Leda, Cocconi, Roberto, Cordova Luna, Maryluz, D’Agaro, Pierlanfranco, Di Bella, Stefano, Di Santolo, Manuela, Dolce, Stefano, Fais, Roberta, Fontana, Francesco, Guerra, Antonietta, Lucarelli, Claudia, Maraglino,, Francesco, Martone, Massimiliano, Maurel, Cristina, Mian, Lucia, Monticelli, Jacopo, Pagotto, Alberto, Parenzan, Ketty, Pezzotti, Patrizio, Pipoli, Alessandro, Roni, Chiara, Sabbatucci,, Michela, Sartor, Assunta, Schincariol, Paolo, Tascini, Carlo, Tosto, Massimiliano, Turello, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347894/
https://www.ncbi.nlm.nih.gov/pubmed/37440346
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.28.2300328
Descripción
Sumario:An outbreak of Ralstonia mannitolilytica bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with R. mannitolilytica. Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with R. mannitolilytica infections (attack rate = 34%; 95% confidence interval: 22.1–47.4). Discontinuation of the contaminated urokinase terminated the outbreak.

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