Cargando…

Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies

BACKGROUND: IDH-wildtype glioblastoma (GBM) is a highly malignant primary brain tumor with a median survival of 15 months after standard of care, which highlights the need for improved therapy. Personalized combination therapy has shown to be successful in many other tumor types and could be benefic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Houweling, Megan, Giczewska, Anna, Abdul, Kulsoom, Nieuwenhuis, Ninke, Küçükosmanoglu, Asli, Pastuszak, Krzysztof, Buijsman, Rogier C, Wesseling, Pieter, Wedekind, Laurine, Noske, David, Supernat, Anna, Bailey, David, Watts, Colin, Wurdinger, Thomas, Westerman, Bart A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347974/ https://www.ncbi.nlm.nih.gov/pubmed/37455945 http://dx.doi.org/10.1093/noajnl/vdad073

Ejemplares similares

Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
por: Giczewska, Anna, et al.
Publicado: (2023)

Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma
por: Brahm, Cyrillo G, et al.
Publicado: (2020)

MEK/MELK inhibition and blood–brain barrier deficiencies in atypical teratoid/rhabdoid tumors
por: Meel, Michaël H, et al.
Publicado: (2020)

Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort
por: van Garderen, Karin A, et al.
Publicado: (2023)

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss
por: Kaur, K, et al.
Publicado: (2009)

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
por: Poulsen, Raewyn C, et al.
Publicado: (2014)

Survival rates of children and young adolescents with CNS tumors improved in the Netherlands since 1990: A population-based study
por: Hoogendijk, Raoull, et al.
Publicado: (2021)

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data
por: Ajaib, Shoaib, et al.
Publicado: (2023)

Single-cell transcriptomic analyses provide insights into the cellular origins and drivers of brain metastasis from lung adenocarcinoma
por: Wang, Zihao, et al.
Publicado: (2023)

Rare central nervous system tumors in adults: a population-based study of ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors
por: Ho, Vincent K Y, et al.
Publicado: (2022)

Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice
por: Qin, Yuan, et al.
Publicado: (2020)

A non-hierarchical organization of tumorigenic NG2 cells in glioblastoma promoted by EGFR
por: Al-Mayhani, Talal F, et al.
Publicado: (2019)

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration
por: Rezk, Rasha, et al.
Publicado: (2020)

imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
por: Pastuszak, Krzysztof, et al.
Publicado: (2021)

Spatial concordance of DNA methylation classification in diffuse glioma
por: Verburg, Niels, et al.
Publicado: (2021)

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness
por: Koessinger, Dominik, et al.
Publicado: (2023)

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma
por: Nasir, Aishah, et al.
Publicado: (2021)

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
por: van Vuurden, Dannis G., et al.
Publicado: (2011)

NCoR controls glioblastoma tumor cell characteristics
por: Heldring, Nina, et al.
Publicado: (2014)

IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas
por: Zhang, Lei, et al.
Publicado: (2018)

Intratumor DNA methylation heterogeneity in glioblastoma: implications for DNA methylation-based classification
por: Wenger, Anna, et al.
Publicado: (2019)

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development
por: Clarke, Alexander J, et al.
Publicado: (2015)

Fluid resuscitation-associated increased mortality and inflammatory cytokine expression in murine polymicrobial sepsis
por: Lee, Young Im, et al.
Publicado: (2017)

Monocyte Siglec-14 expression is upregulated in patients with systemic lupus erythematosus and correlates with lupus disease activity
por: Thornhill, Susannah I., et al.
Publicado: (2017)

Transcriptomic landscape of blood platelets in healthy donors
por: Supernat, Anna, et al.
Publicado: (2021)

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis
por: Chen, Liye, et al.
Publicado: (2016)

Parvovirus B19 activates in vitro normal human dermal fibroblasts: a possible implication in skin fibrosis and systemic sclerosis
por: Arvia, Rosaria, et al.
Publicado: (2020)

Novel, single-beat approach for determining both end-systolic pressure–dimension relationship and preload recruitable stroke work
por: Inuzuka, Ryo, et al.
Publicado: (2016)

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
por: Roberts, Amity R, et al.
Publicado: (2016)

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis
por: Montgomery, Anna B, et al.
Publicado: (2016)

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
por: Johansson, Mikael, et al.
Publicado: (2013)

Targeting the TREM1-positive myeloid microenvironment in glioblastoma
por: Filippova, Natalia, et al.
Publicado: (2022)

Integrating molecular markers into the World Health Organization classification of CNS tumors: a survey of the neuro-oncology community
por: Aldape, Kenneth, et al.
Publicado: (2017)

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities
por: Narayan, Ravi S., et al.
Publicado: (2020)

Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients
por: Rushton, Michael D, et al.
Publicado: (2015)

Optical coherence tomography for serial in vivo imaging of aortic plaque in the rabbit: a preliminary experience
por: Fulcher, Jordan, et al.
Publicado: (2015)

Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis
por: Nwosu, Lilian N, et al.
Publicado: (2016)

Multiomics profiling of paired primary and recurrent glioblastoma patient tissues
por: Dekker, Lennard J M, et al.
Publicado: (2020)

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats
por: Liu, Shie-Chau, et al.
Publicado: (2014)

Intracranially injectable multi-siRNA nanomedicine for the inhibition of glioma stem cells
por: Manju, Cheripelil Abraham, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c17275ei33p2r9qkja92nktev5