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Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study

INTRODUCTION: East-European data on cancer in patients undergoing hemodialysis (HD) are scarce. This study aimed to assess the pattern of cancer and related mortality in patients with end-stage kidney disease (ESKD) undergoing HD. METHODS: Retrospectively analyzing data from 7 HD centers, this study...

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Autores principales: Gadalean, Florica, Ciorcan, Mircea, Apostol, Adrian, Schiller, Oana, Ivan, Viviana, Petrica, Ligia, Bob, Flaviu, Milas, Oana, Simulescu, Anca, Glavan, Mihaela, Parv, Florina, Timar, Bogdan, Timar, Romulus, Schiller, Adalbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348028/
https://www.ncbi.nlm.nih.gov/pubmed/37439202
http://dx.doi.org/10.1080/0886022X.2023.2232046
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author Gadalean, Florica
Ciorcan, Mircea
Apostol, Adrian
Schiller, Oana
Ivan, Viviana
Petrica, Ligia
Bob, Flaviu
Milas, Oana
Simulescu, Anca
Glavan, Mihaela
Parv, Florina
Timar, Bogdan
Timar, Romulus
Schiller, Adalbert
author_facet Gadalean, Florica
Ciorcan, Mircea
Apostol, Adrian
Schiller, Oana
Ivan, Viviana
Petrica, Ligia
Bob, Flaviu
Milas, Oana
Simulescu, Anca
Glavan, Mihaela
Parv, Florina
Timar, Bogdan
Timar, Romulus
Schiller, Adalbert
author_sort Gadalean, Florica
collection PubMed
description INTRODUCTION: East-European data on cancer in patients undergoing hemodialysis (HD) are scarce. This study aimed to assess the pattern of cancer and related mortality in patients with end-stage kidney disease (ESKD) undergoing HD. METHODS: Retrospectively analyzing data from 7 HD centers, this study examined 1377 incident HD patients divided into three groups: no-cancers (NoC), cancers that occurred prior to HD initiation (CPI) and de novo cancer developed after HD initiation (DNC). Mortality risk and survival trends within groups were analyzed using Cox regression and Kaplan-Meier methods. RESULTS: In the cohort, 89.46% of the patients had no cancer (NoC group), 3.63% had cancer before (CPI group), and 6.89% had cancer after HD initiation (DNC group). The mean time from HD initiation to DNC diagnosis was 1 [2.75] years. Older age was associated with a higher risk of developing DNC (p < 0.001). Chronic tubulointerstitial nephritis (CTIN) is more prevalent in cancer patients. The most common cancer sites among DNC patients were the digestive (29.47%) and urinary tracts (18.95%), while those in CPI subjects were hematologic (22%) and digestive (20%). Cancer was an independent predictor of mortality risk (HR = 6.9, 95% [CI]:4.5–10.6, p < 0.001). CONCLUSIONS: East-European ESKD patients undergoing HD have a high incidence of de novo cancers whose primary cancer sites are the digestive and urinary tracts. Almost half of the HD patients with CPI have hematologic and digestive tract cancers. Age and CTIN were associated with cancer risk. Cancer is an independent risk factor for all-cause mortality in patients undergoing hemodialysis (HD).
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spelling pubmed-103480282023-07-15 Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study Gadalean, Florica Ciorcan, Mircea Apostol, Adrian Schiller, Oana Ivan, Viviana Petrica, Ligia Bob, Flaviu Milas, Oana Simulescu, Anca Glavan, Mihaela Parv, Florina Timar, Bogdan Timar, Romulus Schiller, Adalbert Ren Fail Research Article INTRODUCTION: East-European data on cancer in patients undergoing hemodialysis (HD) are scarce. This study aimed to assess the pattern of cancer and related mortality in patients with end-stage kidney disease (ESKD) undergoing HD. METHODS: Retrospectively analyzing data from 7 HD centers, this study examined 1377 incident HD patients divided into three groups: no-cancers (NoC), cancers that occurred prior to HD initiation (CPI) and de novo cancer developed after HD initiation (DNC). Mortality risk and survival trends within groups were analyzed using Cox regression and Kaplan-Meier methods. RESULTS: In the cohort, 89.46% of the patients had no cancer (NoC group), 3.63% had cancer before (CPI group), and 6.89% had cancer after HD initiation (DNC group). The mean time from HD initiation to DNC diagnosis was 1 [2.75] years. Older age was associated with a higher risk of developing DNC (p < 0.001). Chronic tubulointerstitial nephritis (CTIN) is more prevalent in cancer patients. The most common cancer sites among DNC patients were the digestive (29.47%) and urinary tracts (18.95%), while those in CPI subjects were hematologic (22%) and digestive (20%). Cancer was an independent predictor of mortality risk (HR = 6.9, 95% [CI]:4.5–10.6, p < 0.001). CONCLUSIONS: East-European ESKD patients undergoing HD have a high incidence of de novo cancers whose primary cancer sites are the digestive and urinary tracts. Almost half of the HD patients with CPI have hematologic and digestive tract cancers. Age and CTIN were associated with cancer risk. Cancer is an independent risk factor for all-cause mortality in patients undergoing hemodialysis (HD). Taylor & Francis 2023-07-13 /pmc/articles/PMC10348028/ /pubmed/37439202 http://dx.doi.org/10.1080/0886022X.2023.2232046 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Article
Gadalean, Florica
Ciorcan, Mircea
Apostol, Adrian
Schiller, Oana
Ivan, Viviana
Petrica, Ligia
Bob, Flaviu
Milas, Oana
Simulescu, Anca
Glavan, Mihaela
Parv, Florina
Timar, Bogdan
Timar, Romulus
Schiller, Adalbert
Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study
title Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study
title_full Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study
title_fullStr Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study
title_full_unstemmed Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study
title_short Cancer before and after the start of hemodialysis and association with mortality – an Eastern-European multicenter study
title_sort cancer before and after the start of hemodialysis and association with mortality – an eastern-european multicenter study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348028/
https://www.ncbi.nlm.nih.gov/pubmed/37439202
http://dx.doi.org/10.1080/0886022X.2023.2232046
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