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Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis

CONTEXT: Chaihu Jia Longgu Muli Decoction (CLMD) is a traditional Chinese medicine for treating depression. OBJECTIVE: This study investigated the effect of CLMD combined with antidepressants on multimorbidity with depression (MMD). METHOD: Published randomized controlled trials were collected from...

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Autores principales: Jia, Xurui, Chen, Jie, Huang, Ruiou, Wang, Dawei, Wang, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348031/
https://www.ncbi.nlm.nih.gov/pubmed/37439185
http://dx.doi.org/10.1080/13880209.2023.2228356
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author Jia, Xurui
Chen, Jie
Huang, Ruiou
Wang, Dawei
Wang, Xing
author_facet Jia, Xurui
Chen, Jie
Huang, Ruiou
Wang, Dawei
Wang, Xing
author_sort Jia, Xurui
collection PubMed
description CONTEXT: Chaihu Jia Longgu Muli Decoction (CLMD) is a traditional Chinese medicine for treating depression. OBJECTIVE: This study investigated the effect of CLMD combined with antidepressants on multimorbidity with depression (MMD). METHOD: Published randomized controlled trials were collected from PubMed, Web of Science, Chinese National Knowledge Infrastructure, China Science and Technology Journal, Wanfang and China Biomedical Literature Service System Databases. Participants were divided into study groups (CLMD combined with antidepressants) and control groups (antidepressants). RevMan5.4 software was used for data analysis. RESULTS: Hamilton’s Depression Scale score was significantly lower (MD = −5.62, 95%CI [−5.86, −5.37], p < 0.00001), and the effective rate was significantly higher (RR = 1.23, 95%CI [1.17, 1.29], p < 0.00001) in study groups. National Institute of Health Stroke Scale score and Pittsburgh Sleep Quality Index score of study groups were significantly lower (MD = −2.82, 95%CI [−3.84, −1.81], p < 0.00001; MD = −2.26, 95%CI [−3.19, −1.34], p < 0.00001). 5-HT, DA, NE and IL-1β level were significantly lower (SMD = 1.99, p = 0.003; SMD = 1.99, p < 0.00001; SMD = 0.86, p < 0.00001; MD = −14.64, p = 0.003) in study groups. Adverse reaction rate in study groups was significantly lower (RR = 0.47, 95%CI [0.24, 0.91], p = 0.03). The gastrointestinal tract and autonomic nervous system disorders were reduced in study groups. DISCUSSION AND CONCLUSIONS: CLMD combined with antidepressants enhances the effect of antidepressants and reduces their adverse reactions, performing a synergistic effect; it may be considered as an effective option in the treatment of MMD.
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spelling pubmed-103480312023-07-15 Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis Jia, Xurui Chen, Jie Huang, Ruiou Wang, Dawei Wang, Xing Pharm Biol Review Article CONTEXT: Chaihu Jia Longgu Muli Decoction (CLMD) is a traditional Chinese medicine for treating depression. OBJECTIVE: This study investigated the effect of CLMD combined with antidepressants on multimorbidity with depression (MMD). METHOD: Published randomized controlled trials were collected from PubMed, Web of Science, Chinese National Knowledge Infrastructure, China Science and Technology Journal, Wanfang and China Biomedical Literature Service System Databases. Participants were divided into study groups (CLMD combined with antidepressants) and control groups (antidepressants). RevMan5.4 software was used for data analysis. RESULTS: Hamilton’s Depression Scale score was significantly lower (MD = −5.62, 95%CI [−5.86, −5.37], p < 0.00001), and the effective rate was significantly higher (RR = 1.23, 95%CI [1.17, 1.29], p < 0.00001) in study groups. National Institute of Health Stroke Scale score and Pittsburgh Sleep Quality Index score of study groups were significantly lower (MD = −2.82, 95%CI [−3.84, −1.81], p < 0.00001; MD = −2.26, 95%CI [−3.19, −1.34], p < 0.00001). 5-HT, DA, NE and IL-1β level were significantly lower (SMD = 1.99, p = 0.003; SMD = 1.99, p < 0.00001; SMD = 0.86, p < 0.00001; MD = −14.64, p = 0.003) in study groups. Adverse reaction rate in study groups was significantly lower (RR = 0.47, 95%CI [0.24, 0.91], p = 0.03). The gastrointestinal tract and autonomic nervous system disorders were reduced in study groups. DISCUSSION AND CONCLUSIONS: CLMD combined with antidepressants enhances the effect of antidepressants and reduces their adverse reactions, performing a synergistic effect; it may be considered as an effective option in the treatment of MMD. Taylor & Francis 2023-07-13 /pmc/articles/PMC10348031/ /pubmed/37439185 http://dx.doi.org/10.1080/13880209.2023.2228356 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review Article
Jia, Xurui
Chen, Jie
Huang, Ruiou
Wang, Dawei
Wang, Xing
Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
title Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
title_full Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
title_fullStr Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
title_full_unstemmed Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
title_short Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
title_sort effect-enhancing and toxicity-reducing effects of chaihu jia longgu muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348031/
https://www.ncbi.nlm.nih.gov/pubmed/37439185
http://dx.doi.org/10.1080/13880209.2023.2228356
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