PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1–AKT–mTOR/Bcl2 pathway

Recent studies on biphenyl-containing compounds, a type of PD-1/PD-L1 blocker which binds to PD-L1 and induces dimerisation, have focussed on its immune function. Herein, 10 novel biphenyl derivatives were designed and synthesised. The results of the CCK-8 showed that compounds have different anti-t...

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Detalles Bibliográficos
Autores principales: Zhang, Hua, Zhou, Shi-Jia, Shen, Chen-Feng, Zhou, Yong-Nan, Wu, Cai-Yun, Zhu, Meng-Yu, Yu, Qi-Meng, Awadasseid, Annoor, Wu, Yan-Ling, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348038/
https://www.ncbi.nlm.nih.gov/pubmed/37439326
http://dx.doi.org/10.1080/14756366.2023.2230388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348038/
https://www.ncbi.nlm.nih.gov/pubmed/37439326
http://dx.doi.org/10.1080/14756366.2023.2230388

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