A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine

African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicit...

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Autores principales: Liu, Wenming, Li, Hengchun, Liu, Bo, Lv, Tianxing, Yang, Chenchen, Chen, Si, Feng, Liqiang, Lai, Liangxue, Duan, Ziyuan, Chen, Xinwen, Li, Pingchao, Guan, Suhua, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348041/
https://www.ncbi.nlm.nih.gov/pubmed/37401832
http://dx.doi.org/10.1080/22221751.2023.2233643
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author Liu, Wenming
Li, Hengchun
Liu, Bo
Lv, Tianxing
Yang, Chenchen
Chen, Si
Feng, Liqiang
Lai, Liangxue
Duan, Ziyuan
Chen, Xinwen
Li, Pingchao
Guan, Suhua
Chen, Ling
author_facet Liu, Wenming
Li, Hengchun
Liu, Bo
Lv, Tianxing
Yang, Chenchen
Chen, Si
Feng, Liqiang
Lai, Liangxue
Duan, Ziyuan
Chen, Xinwen
Li, Pingchao
Guan, Suhua
Chen, Ling
author_sort Liu, Wenming
collection PubMed
description African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicity of replication-incompetent type-2 adenoviruses carrying African swine fever virus (ASFV) antigens, namely CP204L (p30), E183L (p54), EP402R (CD2v), B646L (p72), and B602L (p72 chaperone). A vaccine cocktail delivered by simultaneous intramuscular (IM) and intranasal (IN) administration robustly elicited both systemic and mucosal immune responses against AFSV in mice and swine and provided highly effective protection against the circulating ASFV strain in farmed pigs. This multi-antigen cocktail vaccine was well tolerated in the vaccinated animals. No significant interference among antigens was observed. The combined IM and IN vaccination using this adenovirus-vectored antigen cocktail vaccine warrants further evaluation for providing safe and effective protection against ASFV infection and transmission.
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spelling pubmed-103480412023-07-15 A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine Liu, Wenming Li, Hengchun Liu, Bo Lv, Tianxing Yang, Chenchen Chen, Si Feng, Liqiang Lai, Liangxue Duan, Ziyuan Chen, Xinwen Li, Pingchao Guan, Suhua Chen, Ling Emerg Microbes Infect Research Article African swine fever (ASF) is an acute and highly contagious lethal infectious disease in swine that severely threatens the global pig industry. At present, a safe and efficacious vaccine is urgently required to prevent and control the disease. In this study, we evaluated the safety and immunogenicity of replication-incompetent type-2 adenoviruses carrying African swine fever virus (ASFV) antigens, namely CP204L (p30), E183L (p54), EP402R (CD2v), B646L (p72), and B602L (p72 chaperone). A vaccine cocktail delivered by simultaneous intramuscular (IM) and intranasal (IN) administration robustly elicited both systemic and mucosal immune responses against AFSV in mice and swine and provided highly effective protection against the circulating ASFV strain in farmed pigs. This multi-antigen cocktail vaccine was well tolerated in the vaccinated animals. No significant interference among antigens was observed. The combined IM and IN vaccination using this adenovirus-vectored antigen cocktail vaccine warrants further evaluation for providing safe and effective protection against ASFV infection and transmission. Taylor & Francis 2023-07-13 /pmc/articles/PMC10348041/ /pubmed/37401832 http://dx.doi.org/10.1080/22221751.2023.2233643 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Article
Liu, Wenming
Li, Hengchun
Liu, Bo
Lv, Tianxing
Yang, Chenchen
Chen, Si
Feng, Liqiang
Lai, Liangxue
Duan, Ziyuan
Chen, Xinwen
Li, Pingchao
Guan, Suhua
Chen, Ling
A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
title A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
title_full A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
title_fullStr A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
title_full_unstemmed A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
title_short A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine
title_sort new vaccination regimen using adenovirus-vectored vaccine confers effective protection against african swine fever virus in swine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348041/
https://www.ncbi.nlm.nih.gov/pubmed/37401832
http://dx.doi.org/10.1080/22221751.2023.2233643
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