Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19

AIM: The present study aimed to determine a correlation between differential TRIM56 expression levels and severe infections of COVID-19 between the Alpha, Delta and Omicron BA.5 variants. MATERIALS & METHODS: This study was performed on 330 COVID-19 patients, including 142 with severe and 188 wi...

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Autores principales: Tavakoli, Rezvan, Rahimi, Pooneh, Hamidi-Fard, Mojtaba, Eybpoosh, Sana, Doroud, Delaram, Ahmadi, Iraj, Anvari, Enayat, Aghasadeghi, Mohammadreza, Fateh, Abolfazl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348059/
http://dx.doi.org/10.2217/fvl-2022-0210
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author Tavakoli, Rezvan
Rahimi, Pooneh
Hamidi-Fard, Mojtaba
Eybpoosh, Sana
Doroud, Delaram
Ahmadi, Iraj
Anvari, Enayat
Aghasadeghi, Mohammadreza
Fateh, Abolfazl
author_facet Tavakoli, Rezvan
Rahimi, Pooneh
Hamidi-Fard, Mojtaba
Eybpoosh, Sana
Doroud, Delaram
Ahmadi, Iraj
Anvari, Enayat
Aghasadeghi, Mohammadreza
Fateh, Abolfazl
author_sort Tavakoli, Rezvan
collection PubMed
description AIM: The present study aimed to determine a correlation between differential TRIM56 expression levels and severe infections of COVID-19 between the Alpha, Delta and Omicron BA.5 variants. MATERIALS & METHODS: This study was performed on 330 COVID-19 patients, including 142 with severe and 188 with mild infections, as well as 160 healthy controls. The levels of TRIM56 gene expression were determined using a qPCR. RESULTS: TRIM56 gene showed significantly lower mRNA expression in the severe and mild groups compared with healthy individuals. Our finding indicated the high and low reduction of TRIM56 mRNA expression in Delta and Omicron BA.5 variant, respectively. CONCLUSION: Further research is needed to characterize the impact of TRIM proteins on the severity of COVID-19.
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spelling pubmed-103480592023-07-15 Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19 Tavakoli, Rezvan Rahimi, Pooneh Hamidi-Fard, Mojtaba Eybpoosh, Sana Doroud, Delaram Ahmadi, Iraj Anvari, Enayat Aghasadeghi, Mohammadreza Fateh, Abolfazl Future Virol Research Article AIM: The present study aimed to determine a correlation between differential TRIM56 expression levels and severe infections of COVID-19 between the Alpha, Delta and Omicron BA.5 variants. MATERIALS & METHODS: This study was performed on 330 COVID-19 patients, including 142 with severe and 188 with mild infections, as well as 160 healthy controls. The levels of TRIM56 gene expression were determined using a qPCR. RESULTS: TRIM56 gene showed significantly lower mRNA expression in the severe and mild groups compared with healthy individuals. Our finding indicated the high and low reduction of TRIM56 mRNA expression in Delta and Omicron BA.5 variant, respectively. CONCLUSION: Further research is needed to characterize the impact of TRIM proteins on the severity of COVID-19. Future Medicine Ltd 2023-07-13 2023-06 /pmc/articles/PMC10348059/ http://dx.doi.org/10.2217/fvl-2022-0210 Text en © 2023 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Tavakoli, Rezvan
Rahimi, Pooneh
Hamidi-Fard, Mojtaba
Eybpoosh, Sana
Doroud, Delaram
Ahmadi, Iraj
Anvari, Enayat
Aghasadeghi, Mohammadreza
Fateh, Abolfazl
Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19
title Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19
title_full Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19
title_fullStr Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19
title_full_unstemmed Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19
title_short Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19
title_sort expression of trim56 gene in sars-cov-2 variants and its relationship with progression of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348059/
http://dx.doi.org/10.2217/fvl-2022-0210
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