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Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are considered the most common mesenchymal tumors of the gastrointestinal tract. Microvessel density (MVD) constitutes a direct method of vascularity quantification and has been associated with survival rates in multiple malignancies. AIM: To appra...

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Autores principales: Perivoliotis, Konstantinos, Baloyiannis, Ioannis, Samara, Athina A, Koutoukoglou, Prodromos, Ntellas, Panagiotis, Dadouli, Katerina, Ioannou, Maria, Tepetes, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348082/
https://www.ncbi.nlm.nih.gov/pubmed/37456971
http://dx.doi.org/10.5662/wjm.v13.i3.153
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author Perivoliotis, Konstantinos
Baloyiannis, Ioannis
Samara, Athina A
Koutoukoglou, Prodromos
Ntellas, Panagiotis
Dadouli, Katerina
Ioannou, Maria
Tepetes, Konstantinos
author_facet Perivoliotis, Konstantinos
Baloyiannis, Ioannis
Samara, Athina A
Koutoukoglou, Prodromos
Ntellas, Panagiotis
Dadouli, Katerina
Ioannou, Maria
Tepetes, Konstantinos
author_sort Perivoliotis, Konstantinos
collection PubMed
description BACKGROUND: Gastrointestinal stromal tumors (GISTs) are considered the most common mesenchymal tumors of the gastrointestinal tract. Microvessel density (MVD) constitutes a direct method of vascularity quantification and has been associated with survival rates in multiple malignancies. AIM: To appraise the effect of MVD on the survival of patients with GIST. METHODS: This study adhered to Systematic reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Electronic scholar databases and grey literature repositories were systematically screened. The Fixed Effects or Random Effects models were used according to the Cochran Q test. RESULTS: In total, 6 eligible studies were identified. The pooled hazard ratio (HR) for disease free survival (DFS) was 8.52 (95%CI: 1.69-42.84, P = 0.009). The odds ratios of disease-free survival between high and low MVD groups at 12 and 60 mo did not reach statistical significance. Significant superiority of the low MVD group in terms of DFS was documented at 36 and 120 mo (OR: 8.46, P < 0.0001 and OR: 22.71, P = 0.0003, respectively) as well as at metastases rate (OR: 0.11, P = 0.0003). CONCLUSION: MVD significantly correlates with the HR of DFS and overall survival rates at 36 and 120 mo. Further prospective studies of higher methodological quality are required.
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spelling pubmed-103480822023-07-15 Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis Perivoliotis, Konstantinos Baloyiannis, Ioannis Samara, Athina A Koutoukoglou, Prodromos Ntellas, Panagiotis Dadouli, Katerina Ioannou, Maria Tepetes, Konstantinos World J Methodol Meta-Analysis BACKGROUND: Gastrointestinal stromal tumors (GISTs) are considered the most common mesenchymal tumors of the gastrointestinal tract. Microvessel density (MVD) constitutes a direct method of vascularity quantification and has been associated with survival rates in multiple malignancies. AIM: To appraise the effect of MVD on the survival of patients with GIST. METHODS: This study adhered to Systematic reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Electronic scholar databases and grey literature repositories were systematically screened. The Fixed Effects or Random Effects models were used according to the Cochran Q test. RESULTS: In total, 6 eligible studies were identified. The pooled hazard ratio (HR) for disease free survival (DFS) was 8.52 (95%CI: 1.69-42.84, P = 0.009). The odds ratios of disease-free survival between high and low MVD groups at 12 and 60 mo did not reach statistical significance. Significant superiority of the low MVD group in terms of DFS was documented at 36 and 120 mo (OR: 8.46, P < 0.0001 and OR: 22.71, P = 0.0003, respectively) as well as at metastases rate (OR: 0.11, P = 0.0003). CONCLUSION: MVD significantly correlates with the HR of DFS and overall survival rates at 36 and 120 mo. Further prospective studies of higher methodological quality are required. Baishideng Publishing Group Inc 2023-06-20 /pmc/articles/PMC10348082/ /pubmed/37456971 http://dx.doi.org/10.5662/wjm.v13.i3.153 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Meta-Analysis
Perivoliotis, Konstantinos
Baloyiannis, Ioannis
Samara, Athina A
Koutoukoglou, Prodromos
Ntellas, Panagiotis
Dadouli, Katerina
Ioannou, Maria
Tepetes, Konstantinos
Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
title Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
title_full Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
title_fullStr Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
title_full_unstemmed Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
title_short Microvessel density in patients with gastrointestinal stromal tumors: A systematic review and meta-analysis
title_sort microvessel density in patients with gastrointestinal stromal tumors: a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348082/
https://www.ncbi.nlm.nih.gov/pubmed/37456971
http://dx.doi.org/10.5662/wjm.v13.i3.153
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