Evolving utility of exosomes in pancreatic cancer management

Despite the development of newer oncological treatment, the survival of patients with pancreatic cancer (PC) remains poor. Recent studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation, metastasis and chemoresistance. Thus, t...

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Autores principales: Anoop, Thattungal Manoharan, Basu, Palash Kumar, Chandramohan, K, Thomas, Ajai, Manoj, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348087/
https://www.ncbi.nlm.nih.gov/pubmed/37456979
http://dx.doi.org/10.5662/wjm.v13.i3.46
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author Anoop, Thattungal Manoharan
Basu, Palash Kumar
Chandramohan, K
Thomas, Ajai
Manoj, S
author_facet Anoop, Thattungal Manoharan
Basu, Palash Kumar
Chandramohan, K
Thomas, Ajai
Manoj, S
author_sort Anoop, Thattungal Manoharan
collection PubMed
description Despite the development of newer oncological treatment, the survival of patients with pancreatic cancer (PC) remains poor. Recent studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation, metastasis and chemoresistance. Thus, the utility of liquid biopsies using exosomes in PC management can be used for early detection, diagnosis, monitoring as well as drug delivery vehicles for cancer therapy. This review summarizes the function, and clinical applications of exosomes in cancers as minimally invasive liquid biomarker in diagnostic, prognostic and therapeutic roles.
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spelling pubmed-103480872023-07-15 Evolving utility of exosomes in pancreatic cancer management Anoop, Thattungal Manoharan Basu, Palash Kumar Chandramohan, K Thomas, Ajai Manoj, S World J Methodol Review Despite the development of newer oncological treatment, the survival of patients with pancreatic cancer (PC) remains poor. Recent studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation, metastasis and chemoresistance. Thus, the utility of liquid biopsies using exosomes in PC management can be used for early detection, diagnosis, monitoring as well as drug delivery vehicles for cancer therapy. This review summarizes the function, and clinical applications of exosomes in cancers as minimally invasive liquid biomarker in diagnostic, prognostic and therapeutic roles. Baishideng Publishing Group Inc 2023-06-20 /pmc/articles/PMC10348087/ /pubmed/37456979 http://dx.doi.org/10.5662/wjm.v13.i3.46 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Anoop, Thattungal Manoharan
Basu, Palash Kumar
Chandramohan, K
Thomas, Ajai
Manoj, S
Evolving utility of exosomes in pancreatic cancer management
title Evolving utility of exosomes in pancreatic cancer management
title_full Evolving utility of exosomes in pancreatic cancer management
title_fullStr Evolving utility of exosomes in pancreatic cancer management
title_full_unstemmed Evolving utility of exosomes in pancreatic cancer management
title_short Evolving utility of exosomes in pancreatic cancer management
title_sort evolving utility of exosomes in pancreatic cancer management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348087/
https://www.ncbi.nlm.nih.gov/pubmed/37456979
http://dx.doi.org/10.5662/wjm.v13.i3.46
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