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T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems

The immune system provides full protection for the body by specifically identifying ‘self’ and removing ‘others’; thus protecting the body from diseases. The immune system includes innate immunity and adaptive immunity, which jointly coordinate the antitumor immune response. T cells, natural killer...

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Autores principales: Yang, Ya-long, Yang, Fei, Huang, Zhuan-qing, Li, Yuan-yuan, Shi, Hao-yuan, Sun, Qi, Ma, Yue, Wang, Yao, Zhang, Ying, Yang, Sen, Zhao, Guan-ren, Xu, Feng-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348220/
https://www.ncbi.nlm.nih.gov/pubmed/37457707
http://dx.doi.org/10.3389/fimmu.2023.1199173
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author Yang, Ya-long
Yang, Fei
Huang, Zhuan-qing
Li, Yuan-yuan
Shi, Hao-yuan
Sun, Qi
Ma, Yue
Wang, Yao
Zhang, Ying
Yang, Sen
Zhao, Guan-ren
Xu, Feng-hua
author_facet Yang, Ya-long
Yang, Fei
Huang, Zhuan-qing
Li, Yuan-yuan
Shi, Hao-yuan
Sun, Qi
Ma, Yue
Wang, Yao
Zhang, Ying
Yang, Sen
Zhao, Guan-ren
Xu, Feng-hua
author_sort Yang, Ya-long
collection PubMed
description The immune system provides full protection for the body by specifically identifying ‘self’ and removing ‘others’; thus protecting the body from diseases. The immune system includes innate immunity and adaptive immunity, which jointly coordinate the antitumor immune response. T cells, natural killer (NK) cells and tumor-associated macrophages (TAMs) are the main tumor-killing immune cells active in three antitumor immune cycle. Cancer immunotherapy focusses on activating and strengthening immune response or eliminating suppression from tumor cells in each step of the cancer-immunity cycle; thus, it strengthens the body’s immunity against tumors. In this review, the antitumor immune cycles of T cells, natural killer (NK) cells and tumor-associated macrophages (TAMs) are discussed. Co-stimulatory and co-inhibitory molecules in the three activity cycles and the development of drugs and delivery systems targeting these molecules are emphasized, and the current state of the art of drug delivery systems for cancer immunotherapy are summarized.
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spelling pubmed-103482202023-07-15 T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems Yang, Ya-long Yang, Fei Huang, Zhuan-qing Li, Yuan-yuan Shi, Hao-yuan Sun, Qi Ma, Yue Wang, Yao Zhang, Ying Yang, Sen Zhao, Guan-ren Xu, Feng-hua Front Immunol Immunology The immune system provides full protection for the body by specifically identifying ‘self’ and removing ‘others’; thus protecting the body from diseases. The immune system includes innate immunity and adaptive immunity, which jointly coordinate the antitumor immune response. T cells, natural killer (NK) cells and tumor-associated macrophages (TAMs) are the main tumor-killing immune cells active in three antitumor immune cycle. Cancer immunotherapy focusses on activating and strengthening immune response or eliminating suppression from tumor cells in each step of the cancer-immunity cycle; thus, it strengthens the body’s immunity against tumors. In this review, the antitumor immune cycles of T cells, natural killer (NK) cells and tumor-associated macrophages (TAMs) are discussed. Co-stimulatory and co-inhibitory molecules in the three activity cycles and the development of drugs and delivery systems targeting these molecules are emphasized, and the current state of the art of drug delivery systems for cancer immunotherapy are summarized. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10348220/ /pubmed/37457707 http://dx.doi.org/10.3389/fimmu.2023.1199173 Text en Copyright © 2023 Yang, Yang, Huang, Li, Shi, Sun, Ma, Wang, Zhang, Yang, Zhao and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Ya-long
Yang, Fei
Huang, Zhuan-qing
Li, Yuan-yuan
Shi, Hao-yuan
Sun, Qi
Ma, Yue
Wang, Yao
Zhang, Ying
Yang, Sen
Zhao, Guan-ren
Xu, Feng-hua
T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
title T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
title_full T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
title_fullStr T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
title_full_unstemmed T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
title_short T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
title_sort t cells, nk cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348220/
https://www.ncbi.nlm.nih.gov/pubmed/37457707
http://dx.doi.org/10.3389/fimmu.2023.1199173
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