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Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study
BACKGROUND: Chordomas have a high risk of recurrence. Radiotherapy (RT) is required as adjuvant therapy after resection. Sufficient radiation doses for local control (LC) can be achieved using either particle therapy, if this technology is available and feasible, or intensity-modulated radiotherapy....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Via Medica
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348326/ https://www.ncbi.nlm.nih.gov/pubmed/37456699 http://dx.doi.org/10.5603/RPOR.a2023.0022 |
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author | Wolf, Robert J. Winkler, Volker Mattke, Matthias Uhl, Matthias Debus, Jürgen |
author_facet | Wolf, Robert J. Winkler, Volker Mattke, Matthias Uhl, Matthias Debus, Jürgen |
author_sort | Wolf, Robert J. |
collection | PubMed |
description | BACKGROUND: Chordomas have a high risk of recurrence. Radiotherapy (RT) is required as adjuvant therapy after resection. Sufficient radiation doses for local control (LC) can be achieved using either particle therapy, if this technology is available and feasible, or intensity-modulated radiotherapy. MATERIALS AND METHODS: 57 patients (age, 11.8–81.6 years) with chordomas of the skull base, spine and pelvis who received photon radiotherapy between 1995 and 2017 were enrolled in the study. Patients were treated at the time of initial diagnosis (68.4%) or during recurrence (31.6%). 44 patients received adjuvant radiotherapy and 13 received definitive radiotherapy. The median total dose to the physical target volume was 70 Gy equivalent dose in 2 Gy fractions (EQD2) (range: 54.7–82.5) in 22–36 fractions. RESULTS: LC was 76.4%, 58.4%, 46.7% and 39.9% and overall survival (OS) was 98.3%, 89%, 76.9% and 47.9% after 1, 3, 5 and 10 years, respectively, with a median follow-up period of 6.5 years (range, 0.5–24.3 years). Age, dose and treatment concept (post-operative or definitive) were significant prognostic factors for OS. Primary treatment, macroscopic tumour at RT and size of the irradiated volume were statistically significant prognostic factors for LC. CONCLUSION: Photon treatment is a safe and effective treatment for chordomas if no particle therapy is available. The best results can be achieved against primary tumours if the application of curative doses is possible due to organs at risk in direct proximity. We recommend high-dose radiotherapy, regardless of the resection status, as part of the initial treatment of chordoma, using the high conformal radiation technique if particle therapy is not feasible. |
format | Online Article Text |
id | pubmed-10348326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Via Medica |
record_format | MEDLINE/PubMed |
spelling | pubmed-103483262023-07-15 Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study Wolf, Robert J. Winkler, Volker Mattke, Matthias Uhl, Matthias Debus, Jürgen Rep Pract Oncol Radiother Research Paper BACKGROUND: Chordomas have a high risk of recurrence. Radiotherapy (RT) is required as adjuvant therapy after resection. Sufficient radiation doses for local control (LC) can be achieved using either particle therapy, if this technology is available and feasible, or intensity-modulated radiotherapy. MATERIALS AND METHODS: 57 patients (age, 11.8–81.6 years) with chordomas of the skull base, spine and pelvis who received photon radiotherapy between 1995 and 2017 were enrolled in the study. Patients were treated at the time of initial diagnosis (68.4%) or during recurrence (31.6%). 44 patients received adjuvant radiotherapy and 13 received definitive radiotherapy. The median total dose to the physical target volume was 70 Gy equivalent dose in 2 Gy fractions (EQD2) (range: 54.7–82.5) in 22–36 fractions. RESULTS: LC was 76.4%, 58.4%, 46.7% and 39.9% and overall survival (OS) was 98.3%, 89%, 76.9% and 47.9% after 1, 3, 5 and 10 years, respectively, with a median follow-up period of 6.5 years (range, 0.5–24.3 years). Age, dose and treatment concept (post-operative or definitive) were significant prognostic factors for OS. Primary treatment, macroscopic tumour at RT and size of the irradiated volume were statistically significant prognostic factors for LC. CONCLUSION: Photon treatment is a safe and effective treatment for chordomas if no particle therapy is available. The best results can be achieved against primary tumours if the application of curative doses is possible due to organs at risk in direct proximity. We recommend high-dose radiotherapy, regardless of the resection status, as part of the initial treatment of chordoma, using the high conformal radiation technique if particle therapy is not feasible. Via Medica 2023-06-26 /pmc/articles/PMC10348326/ /pubmed/37456699 http://dx.doi.org/10.5603/RPOR.a2023.0022 Text en © 2023 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially |
spellingShingle | Research Paper Wolf, Robert J. Winkler, Volker Mattke, Matthias Uhl, Matthias Debus, Jürgen Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
title | Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
title_full | Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
title_fullStr | Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
title_full_unstemmed | Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
title_short | Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
title_sort | intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348326/ https://www.ncbi.nlm.nih.gov/pubmed/37456699 http://dx.doi.org/10.5603/RPOR.a2023.0022 |
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