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Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases

BACKGROUND: Palliative hypofractionated radiotherapy (RT) is an effective mode of treating painful bone metastasis. While 8 Gy single fraction radiation is often effective for the same, for complicated bone metastases a protracted fractionated regimen is preferred, of which 30 Gy/10#/2weeks or 20 Gy...

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Autores principales: Bandyopadhyay, Anis, Ghosh, Arnab Kumar, Chhatui, Bappaditya, Das, Dhiman, Basu, Poulomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348331/
https://www.ncbi.nlm.nih.gov/pubmed/37456707
http://dx.doi.org/10.5603/RPOR.a2023.0018
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author Bandyopadhyay, Anis
Ghosh, Arnab Kumar
Chhatui, Bappaditya
Das, Dhiman
Basu, Poulomi
author_facet Bandyopadhyay, Anis
Ghosh, Arnab Kumar
Chhatui, Bappaditya
Das, Dhiman
Basu, Poulomi
author_sort Bandyopadhyay, Anis
collection PubMed
description BACKGROUND: Palliative hypofractionated radiotherapy (RT) is an effective mode of treating painful bone metastasis. While 8 Gy single fraction radiation is often effective for the same, for complicated bone metastases a protracted fractionated regimen is preferred, of which 30 Gy/10#/2weeks or 20 Gy/5#/1 week are the most common worldwide. However such schedules add to the burden of already overburdened radiation treatment facilities in a busy center, wherein alternative logistic favourable schedules with treatment on weekends are preferred. Here we compare the efficacy of a twice weekly schedule to that of standard continuous 20 Gy/5 #/1 week schedule in terms of pain relief, response and quality of life. MATERIALS AND METHODS: A prospective non randomized study was undertaken from Jan 2018 to May 2019, wherein eligible patients of complicated bone metastases received palliative radiotherapy of 20 Gy/5#, either continuously for 5 fractions from Monday to Saturday or twice weekly, Saturday and Wednesday, starting on a Saturday over about 2 weeks. Pain relief was assessed by the Visual Analogue Scale (VAS) and FACES pain scale recorded prior to starting palliative RT and at 4 weeks, 3 months and 6 months. RESULTS: Thirteen patients received continuous Hypofractionated RT while 16 received it in a twice weekly schedule. Spine was the most common site receiving palliative Radiation (27/29), while breast cancer was the most common primary (16/29). The demographic and the baseline characteristics were comparable. The mean pain score decline at 4 weeks was 2.56 ± 1.1 and 2.71 ± 0.52 in the 5-day and the two-week schedule, respectively (p = 0.67). CONCLUSION: A twice weekly schedule over about two weeks was found to be equivalent in pain control and response to the standard fractionated palliative radiation and, thus, can be safely employed in resource constrained, busy radiotherapy centers.
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spelling pubmed-103483312023-07-15 Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases Bandyopadhyay, Anis Ghosh, Arnab Kumar Chhatui, Bappaditya Das, Dhiman Basu, Poulomi Rep Pract Oncol Radiother Research Paper BACKGROUND: Palliative hypofractionated radiotherapy (RT) is an effective mode of treating painful bone metastasis. While 8 Gy single fraction radiation is often effective for the same, for complicated bone metastases a protracted fractionated regimen is preferred, of which 30 Gy/10#/2weeks or 20 Gy/5#/1 week are the most common worldwide. However such schedules add to the burden of already overburdened radiation treatment facilities in a busy center, wherein alternative logistic favourable schedules with treatment on weekends are preferred. Here we compare the efficacy of a twice weekly schedule to that of standard continuous 20 Gy/5 #/1 week schedule in terms of pain relief, response and quality of life. MATERIALS AND METHODS: A prospective non randomized study was undertaken from Jan 2018 to May 2019, wherein eligible patients of complicated bone metastases received palliative radiotherapy of 20 Gy/5#, either continuously for 5 fractions from Monday to Saturday or twice weekly, Saturday and Wednesday, starting on a Saturday over about 2 weeks. Pain relief was assessed by the Visual Analogue Scale (VAS) and FACES pain scale recorded prior to starting palliative RT and at 4 weeks, 3 months and 6 months. RESULTS: Thirteen patients received continuous Hypofractionated RT while 16 received it in a twice weekly schedule. Spine was the most common site receiving palliative Radiation (27/29), while breast cancer was the most common primary (16/29). The demographic and the baseline characteristics were comparable. The mean pain score decline at 4 weeks was 2.56 ± 1.1 and 2.71 ± 0.52 in the 5-day and the two-week schedule, respectively (p = 0.67). CONCLUSION: A twice weekly schedule over about two weeks was found to be equivalent in pain control and response to the standard fractionated palliative radiation and, thus, can be safely employed in resource constrained, busy radiotherapy centers. Via Medica 2023-06-26 /pmc/articles/PMC10348331/ /pubmed/37456707 http://dx.doi.org/10.5603/RPOR.a2023.0018 Text en © 2023 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially
spellingShingle Research Paper
Bandyopadhyay, Anis
Ghosh, Arnab Kumar
Chhatui, Bappaditya
Das, Dhiman
Basu, Poulomi
Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases
title Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases
title_full Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases
title_fullStr Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases
title_full_unstemmed Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases
title_short Comparison of twice weekly palliative RT versus continuous hypofractionated palliative RT for painful bone metastases
title_sort comparison of twice weekly palliative rt versus continuous hypofractionated palliative rt for painful bone metastases
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348331/
https://www.ncbi.nlm.nih.gov/pubmed/37456707
http://dx.doi.org/10.5603/RPOR.a2023.0018
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