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Atrial natriuretic peptide and leptin interactions in healthy men
INTRODUCTION: Atrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure and natriuresis. ANP also exerts metabolic effects in adipose tissue, liver and skeletal muscle, and interacts with the secretion of adipok...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348356/ https://www.ncbi.nlm.nih.gov/pubmed/37455918 http://dx.doi.org/10.3389/fendo.2023.1195677 |
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author | Daniels, Martin A. Fischer-Posovszky, Pamela Boschmann, Michael Jumpertz-von Schwartzenberg, Reiner Müller, Timo D. Sandforth, Leontine Frank-Podlech, Sabine Hülskämper, Sonja Peter, Andreas Wabitsch, Martin Jordan, Jens Birkenfeld, Andreas L. |
author_facet | Daniels, Martin A. Fischer-Posovszky, Pamela Boschmann, Michael Jumpertz-von Schwartzenberg, Reiner Müller, Timo D. Sandforth, Leontine Frank-Podlech, Sabine Hülskämper, Sonja Peter, Andreas Wabitsch, Martin Jordan, Jens Birkenfeld, Andreas L. |
author_sort | Daniels, Martin A. |
collection | PubMed |
description | INTRODUCTION: Atrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure and natriuresis. ANP also exerts metabolic effects in adipose tissue, liver and skeletal muscle, and interacts with the secretion of adipokines. We tested the hypothesis that ANP lowers concentrations of the anorexigenic adipokine leptin in healthy humans in vivo. METHODS: Human ANP or matching placebo was infused intravenously (iv) into healthy men in a controlled clinical trial. RESULTS: Within 135 minutes of iv ANP infusion, we observed an acute decrease in plasma leptin levels compared to controls. Free fatty acids markedly increased with ANP infusion in vivo, indicating activated lipolysis. In human SGBS adipocytes, ANP suppressed leptin release. DISCUSSION: The study shows that the cardiac hormone ANP reduces the levels of the anorexigenic adipokine leptin in healthy humans, providing further support for ANP as a cardiomyokine in a heart - adipose tissue axis. (registered in the German Clinical Trials Register and the WHO International Clinical Trials Registry Platform was granted under DRKS00024559) |
format | Online Article Text |
id | pubmed-10348356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103483562023-07-15 Atrial natriuretic peptide and leptin interactions in healthy men Daniels, Martin A. Fischer-Posovszky, Pamela Boschmann, Michael Jumpertz-von Schwartzenberg, Reiner Müller, Timo D. Sandforth, Leontine Frank-Podlech, Sabine Hülskämper, Sonja Peter, Andreas Wabitsch, Martin Jordan, Jens Birkenfeld, Andreas L. Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Atrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure and natriuresis. ANP also exerts metabolic effects in adipose tissue, liver and skeletal muscle, and interacts with the secretion of adipokines. We tested the hypothesis that ANP lowers concentrations of the anorexigenic adipokine leptin in healthy humans in vivo. METHODS: Human ANP or matching placebo was infused intravenously (iv) into healthy men in a controlled clinical trial. RESULTS: Within 135 minutes of iv ANP infusion, we observed an acute decrease in plasma leptin levels compared to controls. Free fatty acids markedly increased with ANP infusion in vivo, indicating activated lipolysis. In human SGBS adipocytes, ANP suppressed leptin release. DISCUSSION: The study shows that the cardiac hormone ANP reduces the levels of the anorexigenic adipokine leptin in healthy humans, providing further support for ANP as a cardiomyokine in a heart - adipose tissue axis. (registered in the German Clinical Trials Register and the WHO International Clinical Trials Registry Platform was granted under DRKS00024559) Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10348356/ /pubmed/37455918 http://dx.doi.org/10.3389/fendo.2023.1195677 Text en Copyright © 2023 Daniels, Fischer-Posovszky, Boschmann, Jumpertz-von Schwartzenberg, Müller, Sandforth, Frank-Podlech, Hülskämper, Peter, Wabitsch, Jordan and Birkenfeld https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Daniels, Martin A. Fischer-Posovszky, Pamela Boschmann, Michael Jumpertz-von Schwartzenberg, Reiner Müller, Timo D. Sandforth, Leontine Frank-Podlech, Sabine Hülskämper, Sonja Peter, Andreas Wabitsch, Martin Jordan, Jens Birkenfeld, Andreas L. Atrial natriuretic peptide and leptin interactions in healthy men |
title | Atrial natriuretic peptide and leptin interactions in healthy men |
title_full | Atrial natriuretic peptide and leptin interactions in healthy men |
title_fullStr | Atrial natriuretic peptide and leptin interactions in healthy men |
title_full_unstemmed | Atrial natriuretic peptide and leptin interactions in healthy men |
title_short | Atrial natriuretic peptide and leptin interactions in healthy men |
title_sort | atrial natriuretic peptide and leptin interactions in healthy men |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348356/ https://www.ncbi.nlm.nih.gov/pubmed/37455918 http://dx.doi.org/10.3389/fendo.2023.1195677 |
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