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Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology
Chemokine receptors play a central role in the maintenance of immune homeostasis and development of inflammation by directing leukocyte migration to tissues. GPR15 is a G protein-coupled receptor (GPCR) that was initially known as a co-receptor for human immunodeficiency virus (HIV) and simian immun...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348422/ https://www.ncbi.nlm.nih.gov/pubmed/37457732 http://dx.doi.org/10.3389/fimmu.2023.1179456 |
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author | Okamoto, Yukari Shikano, Sojin |
author_facet | Okamoto, Yukari Shikano, Sojin |
author_sort | Okamoto, Yukari |
collection | PubMed |
description | Chemokine receptors play a central role in the maintenance of immune homeostasis and development of inflammation by directing leukocyte migration to tissues. GPR15 is a G protein-coupled receptor (GPCR) that was initially known as a co-receptor for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV), with structural similarity to other members of the chemoattractant receptor family. Since the discovery of its novel function as a colon-homing receptor of T cells in mice a decade ago, GPR15 has been rapidly gaining attention for its involvement in a variety of inflammatory and immune disorders. The recent identification of its natural ligand C10orf99, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues, has established that GPR15-C10orf99 is a novel signaling axis that controls intestinal homeostasis and inflammation through the migration of immune cells. In addition, it has been demonstrated that C10orf99-independent functions of GPR15 and GPR15-independent activities of C10orf99 also play significant roles in the pathophysiology. Therefore, GPR15 and its ligands are potential therapeutic targets. To provide a basis for the future development of GPR15- or GPR15 ligand-targeted therapeutics, we have summarized the latest advances in the role of GPR15 and its ligands in human diseases as well as the molecular mechanisms that regulate GPR15 expression and functions. |
format | Online Article Text |
id | pubmed-10348422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103484222023-07-15 Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology Okamoto, Yukari Shikano, Sojin Front Immunol Immunology Chemokine receptors play a central role in the maintenance of immune homeostasis and development of inflammation by directing leukocyte migration to tissues. GPR15 is a G protein-coupled receptor (GPCR) that was initially known as a co-receptor for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV), with structural similarity to other members of the chemoattractant receptor family. Since the discovery of its novel function as a colon-homing receptor of T cells in mice a decade ago, GPR15 has been rapidly gaining attention for its involvement in a variety of inflammatory and immune disorders. The recent identification of its natural ligand C10orf99, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues, has established that GPR15-C10orf99 is a novel signaling axis that controls intestinal homeostasis and inflammation through the migration of immune cells. In addition, it has been demonstrated that C10orf99-independent functions of GPR15 and GPR15-independent activities of C10orf99 also play significant roles in the pathophysiology. Therefore, GPR15 and its ligands are potential therapeutic targets. To provide a basis for the future development of GPR15- or GPR15 ligand-targeted therapeutics, we have summarized the latest advances in the role of GPR15 and its ligands in human diseases as well as the molecular mechanisms that regulate GPR15 expression and functions. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10348422/ /pubmed/37457732 http://dx.doi.org/10.3389/fimmu.2023.1179456 Text en Copyright © 2023 Okamoto and Shikano https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Okamoto, Yukari Shikano, Sojin Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology |
title | Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology |
title_full | Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology |
title_fullStr | Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology |
title_full_unstemmed | Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology |
title_short | Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology |
title_sort | emerging roles of a chemoattractant receptor gpr15 and ligands in pathophysiology |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348422/ https://www.ncbi.nlm.nih.gov/pubmed/37457732 http://dx.doi.org/10.3389/fimmu.2023.1179456 |
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