Cargando…
The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination
This report describes a rare case of oligometastatic renal disease in a 69 year-old Caucasian male with non-small cell lung cancer (NSCLC). Diagnosed with Stage IIIb, NSCLC he completed chemoradiotherapy followed by 1 year of immunotherapy. Surveillance CT scans after nearly three years showed an il...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SMC Media Srl
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348430/ https://www.ncbi.nlm.nih.gov/pubmed/37455692 http://dx.doi.org/10.12890/2023_003908 |
_version_ | 1785073665596981248 |
---|---|
author | Matini, Elvis Yogaretnam, Trishhani Wilson, Charlotte Power, Derek |
author_facet | Matini, Elvis Yogaretnam, Trishhani Wilson, Charlotte Power, Derek |
author_sort | Matini, Elvis |
collection | PubMed |
description | This report describes a rare case of oligometastatic renal disease in a 69 year-old Caucasian male with non-small cell lung cancer (NSCLC). Diagnosed with Stage IIIb, NSCLC he completed chemoradiotherapy followed by 1 year of immunotherapy. Surveillance CT scans after nearly three years showed an ill-defined lesion in the left kidney. Biopsy results were consistent with metastasis from the known lung carcinoma. Following neo-adjuvant Pembrolizumab (200mg, q3w), the patient underwent a left radical nephrectomy, without complications. One year post-operatively, CT of the thorax, abdomen and pelvis (TAP) did not identify any recurrence. Renal metastases were historically demonstrated predominantly by autopsy studies([1]). Any mass manifesting in the kidney in the context of previous NSCLC warrants comprehensive investigations. The combination of immunotherapy followed by definitive treatment appears to be a promising management strategy([2]). With regards to local curative options, the advantages and disadvantages of surgery and radiotherapy have been well described([3–4]). LEARNING POINTS: With improved treatment strategies for advanced malignancies, rare cases will continue to emerge and thus, maintaining a high index of suspicion is fundamental. This case demonstrates that immunotherapy increases the efficacy of definitive treatment. |
format | Online Article Text |
id | pubmed-10348430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SMC Media Srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-103484302023-07-15 The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination Matini, Elvis Yogaretnam, Trishhani Wilson, Charlotte Power, Derek Eur J Case Rep Intern Med Article This report describes a rare case of oligometastatic renal disease in a 69 year-old Caucasian male with non-small cell lung cancer (NSCLC). Diagnosed with Stage IIIb, NSCLC he completed chemoradiotherapy followed by 1 year of immunotherapy. Surveillance CT scans after nearly three years showed an ill-defined lesion in the left kidney. Biopsy results were consistent with metastasis from the known lung carcinoma. Following neo-adjuvant Pembrolizumab (200mg, q3w), the patient underwent a left radical nephrectomy, without complications. One year post-operatively, CT of the thorax, abdomen and pelvis (TAP) did not identify any recurrence. Renal metastases were historically demonstrated predominantly by autopsy studies([1]). Any mass manifesting in the kidney in the context of previous NSCLC warrants comprehensive investigations. The combination of immunotherapy followed by definitive treatment appears to be a promising management strategy([2]). With regards to local curative options, the advantages and disadvantages of surgery and radiotherapy have been well described([3–4]). LEARNING POINTS: With improved treatment strategies for advanced malignancies, rare cases will continue to emerge and thus, maintaining a high index of suspicion is fundamental. This case demonstrates that immunotherapy increases the efficacy of definitive treatment. SMC Media Srl 2023-06-07 /pmc/articles/PMC10348430/ /pubmed/37455692 http://dx.doi.org/10.12890/2023_003908 Text en © EFIM 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Article Matini, Elvis Yogaretnam, Trishhani Wilson, Charlotte Power, Derek The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination |
title | The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination |
title_full | The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination |
title_fullStr | The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination |
title_full_unstemmed | The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination |
title_short | The Changing Face of Lung Cancer: Oligometastatic Renal Metastasis Post Chemo-Immunotherapy Combination |
title_sort | changing face of lung cancer: oligometastatic renal metastasis post chemo-immunotherapy combination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348430/ https://www.ncbi.nlm.nih.gov/pubmed/37455692 http://dx.doi.org/10.12890/2023_003908 |
work_keys_str_mv | AT matinielvis thechangingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT yogaretnamtrishhani thechangingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT wilsoncharlotte thechangingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT powerderek thechangingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT matinielvis changingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT yogaretnamtrishhani changingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT wilsoncharlotte changingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination AT powerderek changingfaceoflungcanceroligometastaticrenalmetastasispostchemoimmunotherapycombination |