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How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms
Exposure to any number of stressors during the first 1000 days from conception to age 2 years is important in shaping an individual’s life trajectory of health and disease. Despite the expanding range of stressors as well as later-life phenotypes and outcomes, the underlying molecular mechanisms rem...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348484/ https://www.ncbi.nlm.nih.gov/pubmed/37457711 http://dx.doi.org/10.3389/fimmu.2023.1215544 |
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author | Mposhi, Archibold Turner, Jonathan D. |
author_facet | Mposhi, Archibold Turner, Jonathan D. |
author_sort | Mposhi, Archibold |
collection | PubMed |
description | Exposure to any number of stressors during the first 1000 days from conception to age 2 years is important in shaping an individual’s life trajectory of health and disease. Despite the expanding range of stressors as well as later-life phenotypes and outcomes, the underlying molecular mechanisms remain unclear. Our previous data strongly suggests that early-life exposure to a stressor reduces the capacity of the immune system to generate subsequent generations of naïve cells, while others have shown that, early life stress impairs the capacity of neuronal stem cells to proliferate as they age. This leads us to the “stem cell hypothesis” whereby exposure to adversity during a sensitive period acts through a common mechanism in all the cell types by programming the tissue resident progenitor cells. Furthermore, we review the mechanistic differences observed in fully differentiated cells and suggest that early life adversity (ELA) may alter mitochondria in stem cells. This may consequently alter the destiny of these cells, producing the lifelong “supply” of functionally altered fully differentiated cells. |
format | Online Article Text |
id | pubmed-10348484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103484842023-07-15 How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms Mposhi, Archibold Turner, Jonathan D. Front Immunol Immunology Exposure to any number of stressors during the first 1000 days from conception to age 2 years is important in shaping an individual’s life trajectory of health and disease. Despite the expanding range of stressors as well as later-life phenotypes and outcomes, the underlying molecular mechanisms remain unclear. Our previous data strongly suggests that early-life exposure to a stressor reduces the capacity of the immune system to generate subsequent generations of naïve cells, while others have shown that, early life stress impairs the capacity of neuronal stem cells to proliferate as they age. This leads us to the “stem cell hypothesis” whereby exposure to adversity during a sensitive period acts through a common mechanism in all the cell types by programming the tissue resident progenitor cells. Furthermore, we review the mechanistic differences observed in fully differentiated cells and suggest that early life adversity (ELA) may alter mitochondria in stem cells. This may consequently alter the destiny of these cells, producing the lifelong “supply” of functionally altered fully differentiated cells. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10348484/ /pubmed/37457711 http://dx.doi.org/10.3389/fimmu.2023.1215544 Text en Copyright © 2023 Mposhi and Turner https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Mposhi, Archibold Turner, Jonathan D. How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms |
title | How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms |
title_full | How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms |
title_fullStr | How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms |
title_full_unstemmed | How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms |
title_short | How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms |
title_sort | how can early life adversity still exert an effect decades later? a question of timing, tissues and mechanisms |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348484/ https://www.ncbi.nlm.nih.gov/pubmed/37457711 http://dx.doi.org/10.3389/fimmu.2023.1215544 |
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