Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective

A 53-year-old female, with a known case of adrenocortical carcinoma (ACC), underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for initial staging, which revealed FDG avid large left suprarenal mass contiguous with hypermetabolic tumor thrombus in the in...

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Autores principales: Verma, Priyanka, Chandak, Ashok, Shetye, Suyog Sharad, Nazar, Aamir K., Bagul, Swati Dinesh, Malhotra, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Interesting Image
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348488/
https://www.ncbi.nlm.nih.gov/pubmed/37456196
http://dx.doi.org/10.4103/ijnm.ijnm_186_22
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author Verma, Priyanka
Chandak, Ashok
Shetye, Suyog Sharad
Nazar, Aamir K.
Bagul, Swati Dinesh
Malhotra, Gaurav
author_facet Verma, Priyanka
Chandak, Ashok
Shetye, Suyog Sharad
Nazar, Aamir K.
Bagul, Swati Dinesh
Malhotra, Gaurav
author_sort Verma, Priyanka
collection PubMed
description A 53-year-old female, with a known case of adrenocortical carcinoma (ACC), underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for initial staging, which revealed FDG avid large left suprarenal mass contiguous with hypermetabolic tumor thrombus in the inferior vena cava (IVC) through the left renal vein. Thereafter, she underwent angiogenesis imaging using Ga-68-NODAGA-RGD PET/CT, which showed similar avid tracer uptake in both primary and IVC thrombus. Demonstration of RGD avidity in ACC in this case opens a new horizon for targeted radionuclide therapy (e.g., Lu-177 RGD) in selected patients, who may have limited therapeutic options.
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spelling pubmed-103484882023-07-15 Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective Verma, Priyanka Chandak, Ashok Shetye, Suyog Sharad Nazar, Aamir K. Bagul, Swati Dinesh Malhotra, Gaurav Indian J Nucl Med Interesting Image A 53-year-old female, with a known case of adrenocortical carcinoma (ACC), underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for initial staging, which revealed FDG avid large left suprarenal mass contiguous with hypermetabolic tumor thrombus in the inferior vena cava (IVC) through the left renal vein. Thereafter, she underwent angiogenesis imaging using Ga-68-NODAGA-RGD PET/CT, which showed similar avid tracer uptake in both primary and IVC thrombus. Demonstration of RGD avidity in ACC in this case opens a new horizon for targeted radionuclide therapy (e.g., Lu-177 RGD) in selected patients, who may have limited therapeutic options. Wolters Kluwer - Medknow 2023 2023-06-08 /pmc/articles/PMC10348488/ /pubmed/37456196 http://dx.doi.org/10.4103/ijnm.ijnm_186_22 Text en Copyright: © 2023 Indian Journal of Nuclear Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Interesting Image
Verma, Priyanka
Chandak, Ashok
Shetye, Suyog Sharad
Nazar, Aamir K.
Bagul, Swati Dinesh
Malhotra, Gaurav
Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
title Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
title_full Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
title_fullStr Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
title_full_unstemmed Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
title_short Angiogenesis Imaging of Adrenocortical Carcinoma with Ga-68-NODAGA-RGD Positron Emission Tomography: Opening New Horizons in Multimodality Imaging from Theranostic Perspective
title_sort angiogenesis imaging of adrenocortical carcinoma with ga-68-nodaga-rgd positron emission tomography: opening new horizons in multimodality imaging from theranostic perspective
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348488/
https://www.ncbi.nlm.nih.gov/pubmed/37456196
http://dx.doi.org/10.4103/ijnm.ijnm_186_22
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