F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome

Antiglutamic acid decarboxylase-65 (anti-GAD65) autoantibodies have been identified in variety of rare neurologic disorders most frequently in stiff-person syndrome (SPS), condition characterized by muscle rigidity and overlying painful spasms, typically affecting axial and limb musculature. In anti...

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Autores principales: Kamaleshwaran, Koramadai Karuppusamy, Ramkumar, Elumalai, Senthilkumar, Elumalai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348489/
https://www.ncbi.nlm.nih.gov/pubmed/37456188
http://dx.doi.org/10.4103/ijnm.ijnm_94_22
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author Kamaleshwaran, Koramadai Karuppusamy
Ramkumar, Elumalai
Senthilkumar, Elumalai
author_facet Kamaleshwaran, Koramadai Karuppusamy
Ramkumar, Elumalai
Senthilkumar, Elumalai
author_sort Kamaleshwaran, Koramadai Karuppusamy
collection PubMed
description Antiglutamic acid decarboxylase-65 (anti-GAD65) autoantibodies have been identified in variety of rare neurologic disorders most frequently in stiff-person syndrome (SPS), condition characterized by muscle rigidity and overlying painful spasms, typically affecting axial and limb musculature. In anti-GAD65-related neurologic disorder, malignancy screening is often performed with (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Here, we present an interesting image of 18FFDG PET/CT whole body showing muscle uptake and FDG brain showing thalamic hypometabolism in SPS.
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spelling pubmed-103484892023-07-15 F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome Kamaleshwaran, Koramadai Karuppusamy Ramkumar, Elumalai Senthilkumar, Elumalai Indian J Nucl Med Interesting Image Antiglutamic acid decarboxylase-65 (anti-GAD65) autoantibodies have been identified in variety of rare neurologic disorders most frequently in stiff-person syndrome (SPS), condition characterized by muscle rigidity and overlying painful spasms, typically affecting axial and limb musculature. In anti-GAD65-related neurologic disorder, malignancy screening is often performed with (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Here, we present an interesting image of 18FFDG PET/CT whole body showing muscle uptake and FDG brain showing thalamic hypometabolism in SPS. Wolters Kluwer - Medknow 2023 2023-06-08 /pmc/articles/PMC10348489/ /pubmed/37456188 http://dx.doi.org/10.4103/ijnm.ijnm_94_22 Text en Copyright: © 2023 Indian Journal of Nuclear Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Interesting Image
Kamaleshwaran, Koramadai Karuppusamy
Ramkumar, Elumalai
Senthilkumar, Elumalai
F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome
title F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome
title_full F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome
title_fullStr F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome
title_full_unstemmed F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome
title_short F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-person Syndrome
title_sort f-18 fluorodeoxyglucose positron emission tomography/computed tomography muscle uptake in antiglutamic acid decarboxylase antibody-positive stiff-person syndrome
topic Interesting Image
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348489/
https://www.ncbi.nlm.nih.gov/pubmed/37456188
http://dx.doi.org/10.4103/ijnm.ijnm_94_22
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