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Influence of chronic liver diseases on the course and outcome of COVID-19

INTRODUCTION: Coronavirus disease of 2019 (COVID-19) is a global health problem. The impact of chronic liver diseases on the course and outcome of COVID-19 is still the subject of research. The aim of this study was to show the characteristics of COVID-19 patients with chronic liver diseases, and to...

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Autores principales: Mitrovic, Nikola, Sabanovic, Milos, Vujovic, Ankica, Jovanovic, Jaroslava, Nikolic, Natasa, Jug, Martina, Todorovic, Nevena, Filipovic, Ana, Milosevic, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348559/
https://www.ncbi.nlm.nih.gov/pubmed/37450541
http://dx.doi.org/10.1371/journal.pone.0288350
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author Mitrovic, Nikola
Sabanovic, Milos
Vujovic, Ankica
Jovanovic, Jaroslava
Nikolic, Natasa
Jug, Martina
Todorovic, Nevena
Filipovic, Ana
Milosevic, Ivana
author_facet Mitrovic, Nikola
Sabanovic, Milos
Vujovic, Ankica
Jovanovic, Jaroslava
Nikolic, Natasa
Jug, Martina
Todorovic, Nevena
Filipovic, Ana
Milosevic, Ivana
author_sort Mitrovic, Nikola
collection PubMed
description INTRODUCTION: Coronavirus disease of 2019 (COVID-19) is a global health problem. The impact of chronic liver diseases on the course and outcome of COVID-19 is still the subject of research. The aim of this study was to show the characteristics of COVID-19 patients with chronic liver diseases, and to establish the risk factors for unfavourable outcome. METHODS: A retrospective observational study was conducted at the Infectious Disease Clinic in Belgrade, Serbia, and included 80 patients with chronic liver diseases and COVID-19 within a time frame of two years (between 15 March 2020 and 15 March 2022). Characteristics of the affected persons, as well as the risk factors for a fatal outcome, were analyzed. RESULTS: Of the 80 subjects in the study, 23.8% had chronic viral hepatitis, 12.5% autoimmune liver diseases and alcoholic liver disease respectively, 30% had non-alcoholic fatty liver disease, while 11.2% had chronic liver diseases of unknown aetiology. A total of 33.7% had cirrhosis, 6.3% hepatocellular carcinoma and 5% had liver transplants. A total of 92.5% of respondents had pneumonia (21.2% were critically ill). A deterioration of chronic liver disease was registered among 33.7% of patients, and decompensation in 3.8%; 76.3% patients recovered, while 23.7% had a lethal outcome. Risk factors for lethal outcome by univariate analysis were: alcoholic liver disease, cirrhosis, increased transaminases values prior to COVID-19, malignancy, severe pneumonia and dyspnea. In a multivariate analysis, the presence of liver cirrhosis (OR = 69.1, p = 0.001) and severe pneumonia (OR = 22.3, p = 0.006) remained independently predictive for lethal outcome. CONCLUSION: These findings will help with the evaluation of COVID-19 patients who have chronic liver diseases and will improve their risk stratification.
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spelling pubmed-103485592023-07-15 Influence of chronic liver diseases on the course and outcome of COVID-19 Mitrovic, Nikola Sabanovic, Milos Vujovic, Ankica Jovanovic, Jaroslava Nikolic, Natasa Jug, Martina Todorovic, Nevena Filipovic, Ana Milosevic, Ivana PLoS One Research Article INTRODUCTION: Coronavirus disease of 2019 (COVID-19) is a global health problem. The impact of chronic liver diseases on the course and outcome of COVID-19 is still the subject of research. The aim of this study was to show the characteristics of COVID-19 patients with chronic liver diseases, and to establish the risk factors for unfavourable outcome. METHODS: A retrospective observational study was conducted at the Infectious Disease Clinic in Belgrade, Serbia, and included 80 patients with chronic liver diseases and COVID-19 within a time frame of two years (between 15 March 2020 and 15 March 2022). Characteristics of the affected persons, as well as the risk factors for a fatal outcome, were analyzed. RESULTS: Of the 80 subjects in the study, 23.8% had chronic viral hepatitis, 12.5% autoimmune liver diseases and alcoholic liver disease respectively, 30% had non-alcoholic fatty liver disease, while 11.2% had chronic liver diseases of unknown aetiology. A total of 33.7% had cirrhosis, 6.3% hepatocellular carcinoma and 5% had liver transplants. A total of 92.5% of respondents had pneumonia (21.2% were critically ill). A deterioration of chronic liver disease was registered among 33.7% of patients, and decompensation in 3.8%; 76.3% patients recovered, while 23.7% had a lethal outcome. Risk factors for lethal outcome by univariate analysis were: alcoholic liver disease, cirrhosis, increased transaminases values prior to COVID-19, malignancy, severe pneumonia and dyspnea. In a multivariate analysis, the presence of liver cirrhosis (OR = 69.1, p = 0.001) and severe pneumonia (OR = 22.3, p = 0.006) remained independently predictive for lethal outcome. CONCLUSION: These findings will help with the evaluation of COVID-19 patients who have chronic liver diseases and will improve their risk stratification. Public Library of Science 2023-07-14 /pmc/articles/PMC10348559/ /pubmed/37450541 http://dx.doi.org/10.1371/journal.pone.0288350 Text en © 2023 Mitrovic et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mitrovic, Nikola
Sabanovic, Milos
Vujovic, Ankica
Jovanovic, Jaroslava
Nikolic, Natasa
Jug, Martina
Todorovic, Nevena
Filipovic, Ana
Milosevic, Ivana
Influence of chronic liver diseases on the course and outcome of COVID-19
title Influence of chronic liver diseases on the course and outcome of COVID-19
title_full Influence of chronic liver diseases on the course and outcome of COVID-19
title_fullStr Influence of chronic liver diseases on the course and outcome of COVID-19
title_full_unstemmed Influence of chronic liver diseases on the course and outcome of COVID-19
title_short Influence of chronic liver diseases on the course and outcome of COVID-19
title_sort influence of chronic liver diseases on the course and outcome of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348559/
https://www.ncbi.nlm.nih.gov/pubmed/37450541
http://dx.doi.org/10.1371/journal.pone.0288350
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