Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

Mutations in subunits of the mitochondrial NADH dehydrogenase cause mitochondrial complex I deficiency, a group of severe neurological diseases that can result in death in infancy. The pathogenesis of complex I deficiency remain poorly understood, and as a result there are currently no available tre...

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Detalles Bibliográficos
Autores principales: Granat, Lucy, Knorr, Debbra Y., Ranson, Daniel C., Hamer, Emma L., Chakrabarty, Ram Prosad, Mattedi, Francesca, Fort-Aznar, Laura, Hirth, Frank, Sweeney, Sean T., Vagnoni, Alessio, Chandel, Navdeep S., Bateman, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348588/
https://www.ncbi.nlm.nih.gov/pubmed/37399212
http://dx.doi.org/10.1371/journal.pgen.1010793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348588/
https://www.ncbi.nlm.nih.gov/pubmed/37399212
http://dx.doi.org/10.1371/journal.pgen.1010793

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