Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease

The use of erythropoiesis-stimulating agents (ESAs) reduces the need for recurrent blood transfusions in patients with advanced kidney disease. Rarely, allergic reactions to recombinant human erythropoietin can develop, complicating anemia management due to cross-reactivity between these agents. We...

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Detalles Bibliográficos
Autores principales: Panchal, Hemali, Ali, Saiyed, Hallett, Rosemary, Young, Brian, Wiegley, Nasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348604/
https://www.ncbi.nlm.nih.gov/pubmed/37456430
http://dx.doi.org/10.7759/cureus.40424
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author Panchal, Hemali
Ali, Saiyed
Hallett, Rosemary
Young, Brian
Wiegley, Nasim
author_facet Panchal, Hemali
Ali, Saiyed
Hallett, Rosemary
Young, Brian
Wiegley, Nasim
author_sort Panchal, Hemali
collection PubMed
description The use of erythropoiesis-stimulating agents (ESAs) reduces the need for recurrent blood transfusions in patients with advanced kidney disease. Rarely, allergic reactions to recombinant human erythropoietin can develop, complicating anemia management due to cross-reactivity between these agents. We report the use of an outpatient desensitization protocol, which was successfully completed in an adult patient who developed a maculopapular rash as a form of delayed-type hypersensitivity reaction (DTH) to epoetin-alfa (EPO) use, followed by successful re-introduction of EPO and continued tolerance.
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spelling pubmed-103486042023-07-15 Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease Panchal, Hemali Ali, Saiyed Hallett, Rosemary Young, Brian Wiegley, Nasim Cureus Internal Medicine The use of erythropoiesis-stimulating agents (ESAs) reduces the need for recurrent blood transfusions in patients with advanced kidney disease. Rarely, allergic reactions to recombinant human erythropoietin can develop, complicating anemia management due to cross-reactivity between these agents. We report the use of an outpatient desensitization protocol, which was successfully completed in an adult patient who developed a maculopapular rash as a form of delayed-type hypersensitivity reaction (DTH) to epoetin-alfa (EPO) use, followed by successful re-introduction of EPO and continued tolerance. Cureus 2023-06-14 /pmc/articles/PMC10348604/ /pubmed/37456430 http://dx.doi.org/10.7759/cureus.40424 Text en Copyright © 2023, Panchal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Panchal, Hemali
Ali, Saiyed
Hallett, Rosemary
Young, Brian
Wiegley, Nasim
Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease
title Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease
title_full Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease
title_fullStr Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease
title_full_unstemmed Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease
title_short Successful Prolonged Desensitization to Epoetin-Alfa Hypersensitivity in an Adult Patient With Advanced Chronic Kidney Disease
title_sort successful prolonged desensitization to epoetin-alfa hypersensitivity in an adult patient with advanced chronic kidney disease
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348604/
https://www.ncbi.nlm.nih.gov/pubmed/37456430
http://dx.doi.org/10.7759/cureus.40424
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