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Amyloid fibril structures of tau: Conformational plasticity of the second microtubule-binding repeat
The intrinsically disordered protein tau associates with microtubules in neurons but aggregates into cross–β amyloid fibrils that propagate in neurodegenerative brains. Different tauopathies have different structures for the rigid fibril core. To understand the molecular basis of tau assembly into d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348678/ https://www.ncbi.nlm.nih.gov/pubmed/37450599 http://dx.doi.org/10.1126/sciadv.adh4731 |