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Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness
Proteasomes are the central proteolytic machines that are critical for breaking down most of the damaged and abnormal proteins in human cells. Although universally applicable drugs are not yet available, the stimulation of proteasomal activity is being analyzed as a proof-of-principle strategy to in...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348684/ https://www.ncbi.nlm.nih.gov/pubmed/37450596 http://dx.doi.org/10.1126/sciadv.add5479 |