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Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications

The development and rapid progression of cancer are major social problems. Medical diagnostic techniques and smooth clinical care of cancer are new necessities that must be supported by innovative diagnostic methods and technologies. Current molecular diagnostic tools based on the detection of blood...

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Autores principales: Mahmoodpour, Mehrdad, Kiasari, Bahman Abedi, Karimi, Merat, Abroshan, Arezou, Shamshirian, Danial, Hosseinalizadeh, Hamed, Delavari, Alireza, Mirzei, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348714/
https://www.ncbi.nlm.nih.gov/pubmed/37456253
http://dx.doi.org/10.3389/fonc.2023.1131435
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author Mahmoodpour, Mehrdad
Kiasari, Bahman Abedi
Karimi, Merat
Abroshan, Arezou
Shamshirian, Danial
Hosseinalizadeh, Hamed
Delavari, Alireza
Mirzei, Hamed
author_facet Mahmoodpour, Mehrdad
Kiasari, Bahman Abedi
Karimi, Merat
Abroshan, Arezou
Shamshirian, Danial
Hosseinalizadeh, Hamed
Delavari, Alireza
Mirzei, Hamed
author_sort Mahmoodpour, Mehrdad
collection PubMed
description The development and rapid progression of cancer are major social problems. Medical diagnostic techniques and smooth clinical care of cancer are new necessities that must be supported by innovative diagnostic methods and technologies. Current molecular diagnostic tools based on the detection of blood protein markers are the most common tools for cancer diagnosis. Biosensors have already proven to be a cost-effective and accessible diagnostic tool that can be used where conventional laboratory methods are not readily available. Paper-based biosensors offer a new look at the world of analytical techniques by overcoming limitations through the creation of a simple device with significant advantages such as adaptability, biocompatibility, biodegradability, ease of use, large surface-to-volume ratio, and cost-effectiveness. In this review, we covered the characteristics of exosomes and their role in tumor growth and clinical diagnosis, followed by a discussion of various paper-based biosensors for exosome detection, such as dipsticks, lateral flow assays (LFA), and microfluidic paper-based devices (µPADs). We also discussed the various clinical studies on paper-based biosensors for exosome detection.
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spelling pubmed-103487142023-07-15 Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications Mahmoodpour, Mehrdad Kiasari, Bahman Abedi Karimi, Merat Abroshan, Arezou Shamshirian, Danial Hosseinalizadeh, Hamed Delavari, Alireza Mirzei, Hamed Front Oncol Oncology The development and rapid progression of cancer are major social problems. Medical diagnostic techniques and smooth clinical care of cancer are new necessities that must be supported by innovative diagnostic methods and technologies. Current molecular diagnostic tools based on the detection of blood protein markers are the most common tools for cancer diagnosis. Biosensors have already proven to be a cost-effective and accessible diagnostic tool that can be used where conventional laboratory methods are not readily available. Paper-based biosensors offer a new look at the world of analytical techniques by overcoming limitations through the creation of a simple device with significant advantages such as adaptability, biocompatibility, biodegradability, ease of use, large surface-to-volume ratio, and cost-effectiveness. In this review, we covered the characteristics of exosomes and their role in tumor growth and clinical diagnosis, followed by a discussion of various paper-based biosensors for exosome detection, such as dipsticks, lateral flow assays (LFA), and microfluidic paper-based devices (µPADs). We also discussed the various clinical studies on paper-based biosensors for exosome detection. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10348714/ /pubmed/37456253 http://dx.doi.org/10.3389/fonc.2023.1131435 Text en Copyright © 2023 Mahmoodpour, Kiasari, Karimi, Abroshan, Shamshirian, Hosseinalizadeh, Delavari and Mirzei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Mahmoodpour, Mehrdad
Kiasari, Bahman Abedi
Karimi, Merat
Abroshan, Arezou
Shamshirian, Danial
Hosseinalizadeh, Hamed
Delavari, Alireza
Mirzei, Hamed
Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
title Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
title_full Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
title_fullStr Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
title_full_unstemmed Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
title_short Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
title_sort paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348714/
https://www.ncbi.nlm.nih.gov/pubmed/37456253
http://dx.doi.org/10.3389/fonc.2023.1131435
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