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The comparison of three different molecular imaging methods in localization and grading of insulinoma
AIMS: This cross-sectional study compared the value of molecular imaging (Exendin-4 positron emission tomography/computed tomography [PET/CT], (68)Ga-DOTATATE PET/CT, (18)F- fluorodeoxyglucose [FDG] PET/CT) in insulinoma localization by stratified tumor size and grading, and explored the correlation...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348808/ https://www.ncbi.nlm.nih.gov/pubmed/37455905 http://dx.doi.org/10.3389/fendo.2023.1163176 |
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author | Chang, Lina Bi, Xinyu Li, Shuo Tong, Qi Gu, Yian He, Zonghao Li, Yansheng Chen, Qiusong Cui, Jingqiu Yu, Haonan He, Qing Liu, Ming |
author_facet | Chang, Lina Bi, Xinyu Li, Shuo Tong, Qi Gu, Yian He, Zonghao Li, Yansheng Chen, Qiusong Cui, Jingqiu Yu, Haonan He, Qing Liu, Ming |
author_sort | Chang, Lina |
collection | PubMed |
description | AIMS: This cross-sectional study compared the value of molecular imaging (Exendin-4 positron emission tomography/computed tomography [PET/CT], (68)Ga-DOTATATE PET/CT, (18)F- fluorodeoxyglucose [FDG] PET/CT) in insulinoma localization by stratified tumor size and grading, and explored the correlation of the related the maximum standardized uptake value (SUVmax) with insulinoma grading, Ki-67, maximum tumor diameter, and glucose metabolism. METHODS: In 28 insulinoma patients, the sensitivity of three types of PET/CT for localizing insulinoma was calculated according to tumor size and grade. We compared the SUVmax for different insulinoma grades and analyzed the correlation of SUVmax with Ki-67, maximum tumor diameter, and glucose metabolism indicators. RESULTS: The study included 12 grade (G) 1 and 16 G2 cases, with maximum tumor diameters ranging from 9 to 40 mm. Without differentiation by size and grade, the sensitivity of Exendin-4 PET/CT to localize insulinoma was 100%, which significantly exceeded that of (68)Ga-DOTATATE PET/CT and (18)F-FDG PET/CT (75% and 57%, respectively). In tumors with a maximum diameter ≤ 20 mm and ≤ 15 mm, the sensitivity of Exendin-4 (both 100%) significantly exceeded that of (68)Ga-DOTATATE PET/CT (74% and 64%, respectively) and (18)F-FDG PET/CT (54% and 50%, respectively). In G1 tumors, the sensitivity of Exendin-4 PET/CT was significantly higher than that of (18)F-FDG PET/CT, but not that of (68)Ga-DOTATATE PET/CT, while in G2 tumors, the sensitivity of Exendin-4 PET/CT was significantly higher than that of both other types. However, all three PET/CT types missed a metastatic lymph node in one patient. The (18)F-FDG PET/CT SUVmax was significantly lower than that of the other PET/CT types and that of (68)Ga-DOTATATE PET/CT was significantly lower in G2 than in G1. (68)Ga-DOTATATE PET/CT SUVmax correlated negatively with Ki-67. A receiver operating characteristic (ROC) curve suggested that (68)Ga-DOTATATE PET/CT SUVmax > 19.9 could predict G1 tumors. CONCLUSION: Exendin-4 PET/CT was superior to (68)Ga-DOTATATE PET/CT and (18)F-FDG PET/CT for insulinoma localization, particularly small and G2 tumors, but its diagnostic value in small metastatic lymph nodes requires further exploration. (68)Ga-DOTATATE PET/CT SUVmax could be used as an adjunct to pathology, and a value > 19.9 could predict G1 tumors. No PET/CT SUVmax could predict tumor maximum diameter and glucose metabolism. |
format | Online Article Text |
id | pubmed-10348808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103488082023-07-15 The comparison of three different molecular imaging methods in localization and grading of insulinoma Chang, Lina Bi, Xinyu Li, Shuo Tong, Qi Gu, Yian He, Zonghao Li, Yansheng Chen, Qiusong Cui, Jingqiu Yu, Haonan He, Qing Liu, Ming Front Endocrinol (Lausanne) Endocrinology AIMS: This cross-sectional study compared the value of molecular imaging (Exendin-4 positron emission tomography/computed tomography [PET/CT], (68)Ga-DOTATATE PET/CT, (18)F- fluorodeoxyglucose [FDG] PET/CT) in insulinoma localization by stratified tumor size and grading, and explored the correlation of the related the maximum standardized uptake value (SUVmax) with insulinoma grading, Ki-67, maximum tumor diameter, and glucose metabolism. METHODS: In 28 insulinoma patients, the sensitivity of three types of PET/CT for localizing insulinoma was calculated according to tumor size and grade. We compared the SUVmax for different insulinoma grades and analyzed the correlation of SUVmax with Ki-67, maximum tumor diameter, and glucose metabolism indicators. RESULTS: The study included 12 grade (G) 1 and 16 G2 cases, with maximum tumor diameters ranging from 9 to 40 mm. Without differentiation by size and grade, the sensitivity of Exendin-4 PET/CT to localize insulinoma was 100%, which significantly exceeded that of (68)Ga-DOTATATE PET/CT and (18)F-FDG PET/CT (75% and 57%, respectively). In tumors with a maximum diameter ≤ 20 mm and ≤ 15 mm, the sensitivity of Exendin-4 (both 100%) significantly exceeded that of (68)Ga-DOTATATE PET/CT (74% and 64%, respectively) and (18)F-FDG PET/CT (54% and 50%, respectively). In G1 tumors, the sensitivity of Exendin-4 PET/CT was significantly higher than that of (18)F-FDG PET/CT, but not that of (68)Ga-DOTATATE PET/CT, while in G2 tumors, the sensitivity of Exendin-4 PET/CT was significantly higher than that of both other types. However, all three PET/CT types missed a metastatic lymph node in one patient. The (18)F-FDG PET/CT SUVmax was significantly lower than that of the other PET/CT types and that of (68)Ga-DOTATATE PET/CT was significantly lower in G2 than in G1. (68)Ga-DOTATATE PET/CT SUVmax correlated negatively with Ki-67. A receiver operating characteristic (ROC) curve suggested that (68)Ga-DOTATATE PET/CT SUVmax > 19.9 could predict G1 tumors. CONCLUSION: Exendin-4 PET/CT was superior to (68)Ga-DOTATATE PET/CT and (18)F-FDG PET/CT for insulinoma localization, particularly small and G2 tumors, but its diagnostic value in small metastatic lymph nodes requires further exploration. (68)Ga-DOTATATE PET/CT SUVmax could be used as an adjunct to pathology, and a value > 19.9 could predict G1 tumors. No PET/CT SUVmax could predict tumor maximum diameter and glucose metabolism. Frontiers Media S.A. 2023-06-30 /pmc/articles/PMC10348808/ /pubmed/37455905 http://dx.doi.org/10.3389/fendo.2023.1163176 Text en Copyright © 2023 Chang, Bi, Li, Tong, Gu, He, Li, Chen, Cui, Yu, He and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Chang, Lina Bi, Xinyu Li, Shuo Tong, Qi Gu, Yian He, Zonghao Li, Yansheng Chen, Qiusong Cui, Jingqiu Yu, Haonan He, Qing Liu, Ming The comparison of three different molecular imaging methods in localization and grading of insulinoma |
title | The comparison of three different molecular imaging methods in localization and grading of insulinoma |
title_full | The comparison of three different molecular imaging methods in localization and grading of insulinoma |
title_fullStr | The comparison of three different molecular imaging methods in localization and grading of insulinoma |
title_full_unstemmed | The comparison of three different molecular imaging methods in localization and grading of insulinoma |
title_short | The comparison of three different molecular imaging methods in localization and grading of insulinoma |
title_sort | comparison of three different molecular imaging methods in localization and grading of insulinoma |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348808/ https://www.ncbi.nlm.nih.gov/pubmed/37455905 http://dx.doi.org/10.3389/fendo.2023.1163176 |
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