Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

AIMS: Arrhythmogenic cardiomyopathy (AC) is a severe heart disease predisposing to ventricular arrhythmias and sudden cardiac death caused by mutations affecting intercalated disc (ICD) proteins and aggravated by physical exercise. Recently, autoantibodies targeting ICD proteins, including the desmo...

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Detalles Bibliográficos
Autores principales: Yeruva, Sunil, Stangner, Konstanze, Jungwirth, Anna, Hiermaier, Matthias, Shoykhet, Maria, Kugelmann, Daniela, Hertl, Michael, Egami, Shohei, Ishii, Norito, Koga, Hiroshi, Hashimoto, Takashi, Weis, Michael, Beckmann, Britt-Maria, Biller, Ruth, Schüttler, Dominik, Kääb, Stefan, Waschke, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348947/
https://www.ncbi.nlm.nih.gov/pubmed/37450050
http://dx.doi.org/10.1007/s00018-023-04853-1

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