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Gain-of-function p53(R175H) blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma

Ovarian high-grade serous carcinoma (HGSC) is a highly lethal malignancy for which early detection is a challenge and treatment of late-stage disease is ineffective. HGSC initiation involves exfoliation of fallopian tube epithelial (FTE) cells which form multicellular clusters called spheroids that...

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Detalles Bibliográficos
Autores principales:	Haagsma, Jacob, Kolendowski, Bart, Buensuceso, Adrian, Valdes, Yudith Ramos, DiMattia, Gabriel E., Shepherd, Trevor G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349050/ https://www.ncbi.nlm.nih.gov/pubmed/37452087 http://dx.doi.org/10.1038/s41598-023-38609-5

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