The trigger for pancreatic disease: NLRP3 inflammasome

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this lite...

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Detalles Bibliográficos
Autores principales: Liu, Tianming, Wang, Qiang, Du, Zhiwei, Yin, Lu, Li, Jiachen, Meng, Xianzhi, Xue, Dongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349060/
https://www.ncbi.nlm.nih.gov/pubmed/37452057
http://dx.doi.org/10.1038/s41420-023-01550-7
Descripción
Sumario:NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases. Through this article, we provide a relatively comprehensive summary to the researchers in this field, and provide some targeted therapy routes.

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