The trigger for pancreatic disease: NLRP3 inflammasome

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this lite...

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Detalles Bibliográficos
Autores principales: Liu, Tianming, Wang, Qiang, Du, Zhiwei, Yin, Lu, Li, Jiachen, Meng, Xianzhi, Xue, Dongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349060/
https://www.ncbi.nlm.nih.gov/pubmed/37452057
http://dx.doi.org/10.1038/s41420-023-01550-7
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author Liu, Tianming
Wang, Qiang
Du, Zhiwei
Yin, Lu
Li, Jiachen
Meng, Xianzhi
Xue, Dongbo
author_facet Liu, Tianming
Wang, Qiang
Du, Zhiwei
Yin, Lu
Li, Jiachen
Meng, Xianzhi
Xue, Dongbo
author_sort Liu, Tianming
collection PubMed
description NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases. Through this article, we provide a relatively comprehensive summary to the researchers in this field, and provide some targeted therapy routes.
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spelling pubmed-103490602023-07-16 The trigger for pancreatic disease: NLRP3 inflammasome Liu, Tianming Wang, Qiang Du, Zhiwei Yin, Lu Li, Jiachen Meng, Xianzhi Xue, Dongbo Cell Death Discov Review Article NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases. Through this article, we provide a relatively comprehensive summary to the researchers in this field, and provide some targeted therapy routes. Nature Publishing Group UK 2023-07-14 /pmc/articles/PMC10349060/ /pubmed/37452057 http://dx.doi.org/10.1038/s41420-023-01550-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Liu, Tianming
Wang, Qiang
Du, Zhiwei
Yin, Lu
Li, Jiachen
Meng, Xianzhi
Xue, Dongbo
The trigger for pancreatic disease: NLRP3 inflammasome
title The trigger for pancreatic disease: NLRP3 inflammasome
title_full The trigger for pancreatic disease: NLRP3 inflammasome
title_fullStr The trigger for pancreatic disease: NLRP3 inflammasome
title_full_unstemmed The trigger for pancreatic disease: NLRP3 inflammasome
title_short The trigger for pancreatic disease: NLRP3 inflammasome
title_sort trigger for pancreatic disease: nlrp3 inflammasome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349060/
https://www.ncbi.nlm.nih.gov/pubmed/37452057
http://dx.doi.org/10.1038/s41420-023-01550-7
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