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Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019

Syphilis is a global public health concern. This study aimed to assess the global and regional burden of syphilis from 1990 to 2019. Disease burden was evaluated using disability-adjusted life-years (DALYs) and prevalence. Data were extracted from the 2019 global burden of disease Study, an open dat...

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Autores principales: Chen, Tao, Wan, Bo, Wang, Mingfang, Lin, Su, Wu, Yinlian, Huang, Jiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349077/
https://www.ncbi.nlm.nih.gov/pubmed/37452074
http://dx.doi.org/10.1038/s41598-023-38294-4
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author Chen, Tao
Wan, Bo
Wang, Mingfang
Lin, Su
Wu, Yinlian
Huang, Jiaofeng
author_facet Chen, Tao
Wan, Bo
Wang, Mingfang
Lin, Su
Wu, Yinlian
Huang, Jiaofeng
author_sort Chen, Tao
collection PubMed
description Syphilis is a global public health concern. This study aimed to assess the global and regional burden of syphilis from 1990 to 2019. Disease burden was evaluated using disability-adjusted life-years (DALYs) and prevalence. Data were extracted from the 2019 global burden of disease Study, an open database available for download. Age-standardized rates (ASR) and estimated annual percentage changes (EAPC) were calculated to evaluate the syphilis burden over time. In 2019, the total number of prevalent cases of syphilis was 49.71 million worldwide. The ASR of prevalence was stable from 1990 to 2019 with an EAPC of 0.00 (95% CI − 0.10–0.11). The number of DALYs caused by syphilis was 7.36 million in 2019, reflecting a reduction of 16.38% compared with that in 1990 (8.80 million). The ASR of DALYs exhibited a decreasing trend from 1990 to 2019 (EAPC =  − 1.01; 95% CI − 1.19 to − 0.84), with the highest rates observed in the younger age group (< 14 years old). In 2019, the highest ASR of DALYs was found in low sociodemographic index (SDI) regions (239.21/100,000), and the lowest in high SDI regions (3.14/100,000). Generally, the ASR of DALYs decreased as the SDI increased. The top three countries with the highest ASR of DALYs for syphilis were the Solomon Islands, Equatorial Guinea, and Liberia. While the global prevalence of syphilis remained persistently high from 1990 to 2019, there has been a recent decrease in the ASR of DALYs. Increased attention should be dedicated to younger populations and regions characterized by low SDIs.
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spelling pubmed-103490772023-07-16 Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019 Chen, Tao Wan, Bo Wang, Mingfang Lin, Su Wu, Yinlian Huang, Jiaofeng Sci Rep Article Syphilis is a global public health concern. This study aimed to assess the global and regional burden of syphilis from 1990 to 2019. Disease burden was evaluated using disability-adjusted life-years (DALYs) and prevalence. Data were extracted from the 2019 global burden of disease Study, an open database available for download. Age-standardized rates (ASR) and estimated annual percentage changes (EAPC) were calculated to evaluate the syphilis burden over time. In 2019, the total number of prevalent cases of syphilis was 49.71 million worldwide. The ASR of prevalence was stable from 1990 to 2019 with an EAPC of 0.00 (95% CI − 0.10–0.11). The number of DALYs caused by syphilis was 7.36 million in 2019, reflecting a reduction of 16.38% compared with that in 1990 (8.80 million). The ASR of DALYs exhibited a decreasing trend from 1990 to 2019 (EAPC =  − 1.01; 95% CI − 1.19 to − 0.84), with the highest rates observed in the younger age group (< 14 years old). In 2019, the highest ASR of DALYs was found in low sociodemographic index (SDI) regions (239.21/100,000), and the lowest in high SDI regions (3.14/100,000). Generally, the ASR of DALYs decreased as the SDI increased. The top three countries with the highest ASR of DALYs for syphilis were the Solomon Islands, Equatorial Guinea, and Liberia. While the global prevalence of syphilis remained persistently high from 1990 to 2019, there has been a recent decrease in the ASR of DALYs. Increased attention should be dedicated to younger populations and regions characterized by low SDIs. Nature Publishing Group UK 2023-07-14 /pmc/articles/PMC10349077/ /pubmed/37452074 http://dx.doi.org/10.1038/s41598-023-38294-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chen, Tao
Wan, Bo
Wang, Mingfang
Lin, Su
Wu, Yinlian
Huang, Jiaofeng
Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
title Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
title_full Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
title_fullStr Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
title_full_unstemmed Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
title_short Evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
title_sort evaluating the global, regional, and national impact of syphilis: results from the global burden of disease study 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349077/
https://www.ncbi.nlm.nih.gov/pubmed/37452074
http://dx.doi.org/10.1038/s41598-023-38294-4
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