The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling

The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and as a potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). However, in β cells, which secrete the only glucose-lowering ho...

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Detalles Bibliográficos
Autores principales: Liu, Na, Li, Rui, Cao, Jinglin, Song, Xinyao, Ma, Wenmiao, Liu, Tengli, Wang, Le, Zou, Jiaqi, Zhang, Boya, Liu, Zewen, Liang, Rui, Zheng, Rongxiu, Wang, Shusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349081/
https://www.ncbi.nlm.nih.gov/pubmed/37452039
http://dx.doi.org/10.1038/s41420-023-01506-x

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